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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice/help for high shbg guy
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<blockquote data-quote="madman" data-source="post: 207396" data-attributes="member: 13851"><p>Need a more thorough set of labs.</p><p></p><p>Keep in mind that dysfunction thyroid/adrenals can easily mimic low-t symptoms.</p><p></p><p>Yes, men with what would be considered normal/robust T levels can still have lowish/low FT due to highish/high SHBG.</p><p></p><p>Although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects.</p><p></p><p>Even then it is critical to use the most accurate assays TT/estradiol (LC/MS-MS) and FT (Equilibrium Dialysis or Ultrafiltration).</p><p></p><p>The only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best).</p><p></p><p>I would not rely upon inaccurate assays (direct immunoassay) let alone outdated calculated methods especially in cases of altered SHBG.</p><p></p><p>Good chance that depending on where your current TT/SHBG sits that you may very well have lowish/low FT but even then I would retest using the most accurate assays ED or UF especially seeing as you have high SHBG before jumping to any conclusion that your FT is truly lowish/low!</p></blockquote><p></p>
[QUOTE="madman, post: 207396, member: 13851"] Need a more thorough set of labs. Keep in mind that dysfunction thyroid/adrenals can easily mimic low-t symptoms. Yes, men with what would be considered normal/robust T levels can still have lowish/low FT due to highish/high SHBG. Although TT is important to know FT is what truly matters as it is the active unbound fraction of testosterone responsible for the positive effects. Even then it is critical to use the most accurate assays TT/estradiol (LC/MS-MS) and FT (Equilibrium Dialysis or Ultrafiltration). The only way to know where your FT level truly sits is to have it tested using the most accurate assays such as the gold standard Equilibrium Dialysis or Ultrafiltration (next best). I would not rely upon inaccurate assays (direct immunoassay) let alone outdated calculated methods especially in cases of altered SHBG. Good chance that depending on where your current TT/SHBG sits that you may very well have lowish/low FT but even then I would retest using the most accurate assays ED or UF especially seeing as you have high SHBG before jumping to any conclusion that your FT is truly lowish/low! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice/help for high shbg guy
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