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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice for your younger self- TRT Journey
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<blockquote data-quote="madman" data-source="post: 204579" data-attributes="member: 13851"><p>Most men on trt are using injections (esterified T) or transdermal (gels/creams).</p><p></p><p>Cypionate/enanthate are the most commonly used esters.</p><p></p><p>My advice would be to start low and go slow.</p><p></p><p>Give the protocol a fighting chance (12 weeks).</p><p></p><p>Patience is key!</p><p></p><p>Unfortunately many lack the understanding of how exogenous T works.</p><p></p><p></p><p><strong>*This should be hammered into every patient's head before starting trt or tweaking a protocol (dose T/injection frequency).</strong></p><p></p><p>Keep in mind many fail to realize that when starting trt or tweaking a protocol (dose T/injection frequency) that <strong><em>hormones will be in flux during the weeks leading up until blood levels stabilize (4-6 weeks when using TC/TE)</em></strong> and it is common for many during this transition to experience what we call the <u><em><strong>honeymoon period where there may be a strong increase in libido/erections and overall euphoric feeling due to increasing T levels/dopamine</strong></em></u><strong><em>.</em></strong></p><p></p><p>Unfortunately, this is temporary and short-lived for most as the body will eventually adjust.</p><p></p><p>It is also very common for many men to experience ups/downs in energy/mood/libido/erections/recovery <strong><em>during the transition as the body is trying to adjust which can be very misleading.</em></strong></p><p><strong><em></em></strong></p><p><strong><em>Even then do understand that once blood levels have stabilized (4-6 weeks) it will take another 2-3 months for the body to fully adapt to those new levels and this is the <u>critical time period when one should gauge how they truly feel overall regarding relief/improvement of low-t symptoms</u>.</em></strong></p><p></p><p>When looking at the big picture the first 4-6 weeks is very misleading for most!</p><p></p><p></p><p></p><p></p><p><strong>26.What is a reasonable timeline to begin to observe improvements in the signs and symptoms of testosterone deficiency?</strong></p><p></p><p><em><strong>*<u>Following the initiation of testosterone therapy, serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD</u>.76,77 As such, patients should be counseled that symptom response will not be immediate. Expectations for treatment response should be established with each patient. Patients can anticipate improvements in many of the common symptoms of TD (libido, energy levels, sexual function) after 3 months of treatment or longer. Metabolic and structural (body composition, muscle mass, bone density) changes may take upwards of 6-months. 77 In addition, patients should be counseled that diet and exercise in combination with testosterone therapy are recommended for body composition changes.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Appreciating this pattern of response to testosterone therapy is fundamental when determining the impact of treatment and the appropriate timing of follow-up evaluations while on therapy.</strong></em><strong><em> <u>For example, if patients undergo a symptom review and measurement of testosterone levels too early (< 3 months), it may lead both physicians and patients to conclude that the treatment has not been impactful (i.e. normal levels of testosterone without symptomatic/structural/metabolic benefit)</u>. <u>However, if the same assessment was scheduled 3-6 months after the initiation of therapy, the clinical response tends to be more reflective of normalized levels of serum testosterone</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 204579, member: 13851"] Most men on trt are using injections (esterified T) or transdermal (gels/creams). Cypionate/enanthate are the most commonly used esters. My advice would be to start low and go slow. Give the protocol a fighting chance (12 weeks). Patience is key! Unfortunately many lack the understanding of how exogenous T works. [B]*This should be hammered into every patient's head before starting trt or tweaking a protocol (dose T/injection frequency).[/B] Keep in mind many fail to realize that when starting trt or tweaking a protocol (dose T/injection frequency) that [B][I]hormones will be in flux during the weeks leading up until blood levels stabilize (4-6 weeks when using TC/TE)[/I][/B] and it is common for many during this transition to experience what we call the [U][I][B]honeymoon period where there may be a strong increase in libido/erections and overall euphoric feeling due to increasing T levels/dopamine[/B][/I][/U][B][I].[/I][/B] Unfortunately, this is temporary and short-lived for most as the body will eventually adjust. It is also very common for many men to experience ups/downs in energy/mood/libido/erections/recovery [B][I]during the transition as the body is trying to adjust which can be very misleading. Even then do understand that once blood levels have stabilized (4-6 weeks) it will take another 2-3 months for the body to fully adapt to those new levels and this is the [U]critical time period when one should gauge how they truly feel overall regarding relief/improvement of low-t symptoms[/U].[/I][/B] When looking at the big picture the first 4-6 weeks is very misleading for most! [B]26.What is a reasonable timeline to begin to observe improvements in the signs and symptoms of testosterone deficiency?[/B] [I][B]*[U]Following the initiation of testosterone therapy, serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD[/U].76,77 As such, patients should be counseled that symptom response will not be immediate. Expectations for treatment response should be established with each patient. Patients can anticipate improvements in many of the common symptoms of TD (libido, energy levels, sexual function) after 3 months of treatment or longer. Metabolic and structural (body composition, muscle mass, bone density) changes may take upwards of 6-months. 77 In addition, patients should be counseled that diet and exercise in combination with testosterone therapy are recommended for body composition changes. *Appreciating this pattern of response to testosterone therapy is fundamental when determining the impact of treatment and the appropriate timing of follow-up evaluations while on therapy.[/B][/I][B][I] [U]For example, if patients undergo a symptom review and measurement of testosterone levels too early (< 3 months), it may lead both physicians and patients to conclude that the treatment has not been impactful (i.e. normal levels of testosterone without symptomatic/structural/metabolic benefit)[/U]. [U]However, if the same assessment was scheduled 3-6 months after the initiation of therapy, the clinical response tends to be more reflective of normalized levels of serum testosterone[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Advice for your younger self- TRT Journey
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