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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Adipsia/Complete Loss of Thirst + Skin Elasticity Changes
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<blockquote data-quote="JustPanicNoDisco" data-source="post: 196396" data-attributes="member: 42100"><p>To preface this, I've been on TRT at 200mg/wk, daily IM, for 8 weeks. I recently got labs and sodium, potassium, chloride and all blood markers came back within normal range.</p><p></p><p>Before starting TRT, my thirst levels were normal and I didn’t have these… skin elasticity issues. I don't know exactly when they started, but I noticed them within the first 3-4 weeks. I’ve scoured the forum and web, but I really can’t find anything. I know hormones can change fluid dynamics (estrogen increasing water retention and such), but I’m not a biochemist or doctor. If anyone can help me solve this mystery, it would be fabulous.</p><p></p><p>Since starting TRT, I’ve completely lost my sense of thirst, suggesting that there is potentially an issue with hypothalamic signaling/antidiuretic hormone release due to urine solute concentration issues. As said above, my potassium, chloride, and sodium numbers in serum are normal. I haven't had any urine testing conducted. </p><p></p><p>When I got bloods done at 8 weeks, my E2 was in range and T was above range. The ratio looked good. For reference, the following numbers are here.</p><p></p><p>[MEDIA=imgur]a/N3fthDh[/MEDIA]</p><p></p><p>Anyway, I have also noticed changes in skin elasticity. For example, when I’m bent over for long periods, I notice the skin below my pecs becomes creased, and it takes several minutes for this to go away upon sitting up again in an upright position. Additionally, when I flex my arms, the skin almost rolls/creases back toward my bicep (I’m fairly lean, so I don’t think this is fat, and it only started after starting TRT).</p><p></p><p>Here are some additional pictures:</p><p></p><p>[MEDIA=imgur]XzrXvwt[/MEDIA] - flexing quad causes ‘wrinkling’ of skin around knee</p><p>[MEDIA=imgur]yJNUzIz[/MEDIA] - flexing bicep causes skin to “roll up”</p><p>[MEDIA=imgur]xgg5yf6[/MEDIA] - 2nd view of bicep flex</p><p>[MEDIA=imgur]fqVMOCu[/MEDIA] - creases around armipit area that weren’t previously there.</p><p></p><p>Has anybody else experienced this? Per google, it seems like it’s related to severe dehydration, but if I was that dehydrated, my veins would be much flatter than they are in the last picture. I've also been consciously drinking lots of water despite my lack of thirst. Is this due to water retention? It’s just too strange that I developed both adipsia and these skin changes at the same time.</p><p></p><p>I know most of you aren’t medical experts, but I’m guessing someone out there has some ideas about this or has experienced it themselves.</p></blockquote><p></p>
[QUOTE="JustPanicNoDisco, post: 196396, member: 42100"] To preface this, I've been on TRT at 200mg/wk, daily IM, for 8 weeks. I recently got labs and sodium, potassium, chloride and all blood markers came back within normal range. Before starting TRT, my thirst levels were normal and I didn’t have these… skin elasticity issues. I don't know exactly when they started, but I noticed them within the first 3-4 weeks. I’ve scoured the forum and web, but I really can’t find anything. I know hormones can change fluid dynamics (estrogen increasing water retention and such), but I’m not a biochemist or doctor. If anyone can help me solve this mystery, it would be fabulous. Since starting TRT, I’ve completely lost my sense of thirst, suggesting that there is potentially an issue with hypothalamic signaling/antidiuretic hormone release due to urine solute concentration issues. As said above, my potassium, chloride, and sodium numbers in serum are normal. I haven't had any urine testing conducted. When I got bloods done at 8 weeks, my E2 was in range and T was above range. The ratio looked good. For reference, the following numbers are here. [MEDIA=imgur]a/N3fthDh[/MEDIA] Anyway, I have also noticed changes in skin elasticity. For example, when I’m bent over for long periods, I notice the skin below my pecs becomes creased, and it takes several minutes for this to go away upon sitting up again in an upright position. Additionally, when I flex my arms, the skin almost rolls/creases back toward my bicep (I’m fairly lean, so I don’t think this is fat, and it only started after starting TRT). Here are some additional pictures: [MEDIA=imgur]XzrXvwt[/MEDIA] - flexing quad causes ‘wrinkling’ of skin around knee [MEDIA=imgur]yJNUzIz[/MEDIA] - flexing bicep causes skin to “roll up” [MEDIA=imgur]xgg5yf6[/MEDIA] - 2nd view of bicep flex [MEDIA=imgur]fqVMOCu[/MEDIA] - creases around armipit area that weren’t previously there. Has anybody else experienced this? Per google, it seems like it’s related to severe dehydration, but if I was that dehydrated, my veins would be much flatter than they are in the last picture. I've also been consciously drinking lots of water despite my lack of thirst. Is this due to water retention? It’s just too strange that I developed both adipsia and these skin changes at the same time. I know most of you aren’t medical experts, but I’m guessing someone out there has some ideas about this or has experienced it themselves. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Adipsia/Complete Loss of Thirst + Skin Elasticity Changes
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