ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 122007" data-attributes="member: 13851"><p>In conclusion, all together, our results suggest the possibility that the persistently high E2 levels associated with obesity leads to ESR1 downregulation in adipocytes and reduced E2 sensitivity, which in turn results in attenuated fat mass loss in response to T therapy. Oestrogen resistance induced obesity was first described in a man with an inactivating mutation of the ESR1 [10]. Lack of E2 action predispose to metabolic syndrome, type 2 diabetes and cardiovascular events [6], conditions that affect both genders [8]. The identification of optimum serum E2 associated with the best E2 sensitivity and body composition profile is of clinical relevance, especially considering its influence on the response to hormone therapy as observed in our study. This is the first study showing: (1) the optimum E2 levels</p><p>associated with better body composition in HG men, (2) the existence of different E2 sensitivity based on circulating E2 and (3) its influence on the response to T therapy. Prospective investigations with a bigger sample size are needed to confirm our observation and to explore consequences of E2 resistance among individuals with hyperestrogenemia.</p></blockquote><p></p>
[QUOTE="madman, post: 122007, member: 13851"] In conclusion, all together, our results suggest the possibility that the persistently high E2 levels associated with obesity leads to ESR1 downregulation in adipocytes and reduced E2 sensitivity, which in turn results in attenuated fat mass loss in response to T therapy. Oestrogen resistance induced obesity was first described in a man with an inactivating mutation of the ESR1 [10]. Lack of E2 action predispose to metabolic syndrome, type 2 diabetes and cardiovascular events [6], conditions that affect both genders [8]. The identification of optimum serum E2 associated with the best E2 sensitivity and body composition profile is of clinical relevance, especially considering its influence on the response to hormone therapy as observed in our study. This is the first study showing: (1) the optimum E2 levels associated with better body composition in HG men, (2) the existence of different E2 sensitivity based on circulating E2 and (3) its influence on the response to T therapy. Prospective investigations with a bigger sample size are needed to confirm our observation and to explore consequences of E2 resistance among individuals with hyperestrogenemia. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top