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General Health & Fitness
Nutrition and Supplements
Acute effects of Nitrosigine® and citrulline malate on vasodilation
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<blockquote data-quote="madman" data-source="post: 172780" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">Abstract </span></strong></p><p></p><p><strong>Background:</strong> Athletes are increasingly exploring ways to enhance their physical performance. Increasing blood flow to the working tissues through endothelium-dependent vasodilation is one factor athletes use to realize these results. Sports supplements such as pre-workouts tout this benefit; however, many have not been tested under laboratory conditions to examine the effects of commonly used supplements on vasodilation. Two popular supplements are Nitrosigine® and citrulline malate (CM). Thus, the purpose of this experiment was to determine the effective of Nitrosigine and CM on vasodilation using ultrasound and flow mediated dilation (FMD).</p><p></p><p><strong>Methods:</strong> Healthy, normotensive, and physically active male (n = 16) and female (n = 8) young adults participated in the present investigation. We utilized a randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period. Baseline FMD measurement was obtained for each visit, <span style="color: rgb(44, 130, 201)">followed by consumption of one clinical dose CM (8 g), Nitrosigine (1.5 g), or dextrose placebo (8 g).</span> Following a 60-min digestion period, FMD was repeated. Supplementation order was randomized controlling for potential order effects.</p><p></p><p><strong>Results:</strong> Repeated measures ANOVA yielded a significant supplement (3) x time (2) effect (p < .001), such that Nitrosigine and CM yielded a greater improvement in FMD response than placebo. After supplementation, Nitrosigine and CM increased FMD by 31 and 34%, respectively, compared to a decrease of 2% during the placebo trial. After allometric scaling of the FMD values, supplement x time effect remained significant (p = .001) and changes were similar to non-scaled results. Nitrosigine (23%) and CM (25%) generated significantly greater allometric scaled FMD values when compared to the placebo trail (0.60%).</p><p></p><p><strong>Discussion:</strong> <span style="color: rgb(184, 49, 47)">Both Nitrosigine and CM increased endothelial-dependent vasodilation as measured by a change in FMD. Increased vasodilation leads to an increase in skeletal muscle blood flow resulting in potential improvements in exercise performance. </span></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusions </strong></p><p></p><p><span style="color: rgb(184, 49, 47)">Results from this study support a novel finding that acute supplementation with CM and Nitrosigine can improve endothelial-dependent vasodilation in trained young adults.</span> Prior to this study, there was no comparison of CM and Nitrosigine effects using FMD. <span style="color: rgb(184, 49, 47)">This study supports previous research findings that Nitrosigine may be a beneficial pre-workout supplement, and that a 1.5 g dose of Nitrosigine may be equally as effective at increasing endothelial response as a larger 8 g dose of CM.</span></p></blockquote><p></p>
[QUOTE="madman, post: 172780, member: 13851"] [B][COLOR=rgb(184, 49, 47)]Abstract [/COLOR][/B] [B]Background:[/B] Athletes are increasingly exploring ways to enhance their physical performance. Increasing blood flow to the working tissues through endothelium-dependent vasodilation is one factor athletes use to realize these results. Sports supplements such as pre-workouts tout this benefit; however, many have not been tested under laboratory conditions to examine the effects of commonly used supplements on vasodilation. Two popular supplements are Nitrosigine® and citrulline malate (CM). Thus, the purpose of this experiment was to determine the effective of Nitrosigine and CM on vasodilation using ultrasound and flow mediated dilation (FMD). [B]Methods:[/B] Healthy, normotensive, and physically active male (n = 16) and female (n = 8) young adults participated in the present investigation. We utilized a randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period. Baseline FMD measurement was obtained for each visit, [COLOR=rgb(44, 130, 201)]followed by consumption of one clinical dose CM (8 g), Nitrosigine (1.5 g), or dextrose placebo (8 g).[/COLOR] Following a 60-min digestion period, FMD was repeated. Supplementation order was randomized controlling for potential order effects. [B]Results:[/B] Repeated measures ANOVA yielded a significant supplement (3) x time (2) effect (p < .001), such that Nitrosigine and CM yielded a greater improvement in FMD response than placebo. After supplementation, Nitrosigine and CM increased FMD by 31 and 34%, respectively, compared to a decrease of 2% during the placebo trial. After allometric scaling of the FMD values, supplement x time effect remained significant (p = .001) and changes were similar to non-scaled results. Nitrosigine (23%) and CM (25%) generated significantly greater allometric scaled FMD values when compared to the placebo trail (0.60%). [B]Discussion:[/B] [COLOR=rgb(184, 49, 47)]Both Nitrosigine and CM increased endothelial-dependent vasodilation as measured by a change in FMD. Increased vasodilation leads to an increase in skeletal muscle blood flow resulting in potential improvements in exercise performance. [/COLOR] [B]Conclusions [/B] [COLOR=rgb(184, 49, 47)]Results from this study support a novel finding that acute supplementation with CM and Nitrosigine can improve endothelial-dependent vasodilation in trained young adults.[/COLOR] Prior to this study, there was no comparison of CM and Nitrosigine effects using FMD. [COLOR=rgb(184, 49, 47)]This study supports previous research findings that Nitrosigine may be a beneficial pre-workout supplement, and that a 1.5 g dose of Nitrosigine may be equally as effective at increasing endothelial response as a larger 8 g dose of CM.[/COLOR] [/QUOTE]
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Acute effects of Nitrosigine® and citrulline malate on vasodilation
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