Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle

[madman]

Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and represents the most common skin disease affecting about 85% of adolescents in Westernized populations. Acne vulgaris is primarily a disease of wealthy countries and exhibits higher prevalence rates in developed compared with developing countries. No acne has been found in non-Westernized populations still living under Paleolithic dietary conditions constraining hyperglycemic carbohydrates, milk, and dairy products. The high prevalence rates of adolescent acne cannot be explained by the predominance of genetic factors but by the influence of a Western diet that overstimulates the key conductor of metabolism, the nutrient- and growth factor–sensitive kinase mTORC1. Increased mTORC1 activity has been detected in lesional skin and sebaceous glands of acne patients compared with acne-free controls. Increased mTORC1 signaling is a characteristic feature of insulin resistance, obesity, type 2 diabetes mellitus, cancer, and neurodegenerative diseases. Acne vulgaris is a family member of mTORC1-driven diseases of civilization and represents the MetS of the sebaceous follicle.

https://www.sciencedirect.com/science/article/pii/S0738081X1730161X?via=ihub

 

[Jinzang]

I think the article is advising a no dairy and low glycemic index diet. Get rid of the whey protein and sugary foods first.

 

[bfoley]

Good article. I have rosacea and seb derm and always wondered if there was link between diet and my skin condition. My dermatologist says no, but I'm no too sure about what she says.

Interesting about the whey and casein. I have been using whey in my protein shakes for a long time. I'm going to try to reduce the amount of whey I take every day and see if that improves my skin condition.