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General Health & Fitness
Health & Wellness
Acid Reflux and GERD Treatement
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<blockquote data-quote="FunkOdyssey" data-source="post: 233483" data-attributes="member: 44064"><p>I haven't mentioned this previously but I definitely see worsened reflux from TRT. When I first started it was brutal. I suspect the mechanism involves beta adrenergic stimulation:</p><p></p><p>[URL unfurl="true"]https://gut.bmj.com/content/gutjnl/27/3/260.full.pdf[/URL]</p><p>[ATTACH=full]25399[/ATTACH]</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/11591558/[/URL]</p><p></p><p></p><p>[USER=38590]@readalot[/USER] is familiar with the effects of TRT on beta adrenergic receptors and might be able to elaborate. I've seen enough complaints of TRT-exaggerated GERD / reflux symptoms on Reddit that I do think it's a real thing. There might be other mechanisms at work also. Higher E2 is associated with GERD in women and has lower esophageal sphincter relaxant effects:</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689967/[/URL]</p><p></p><p></p><p>This exaggeration of reflux by TRT seems worst when I first started and whenever I increase the dose. At least partial tolerance seems to build relatively quickly (within 1-2 weeks). I'm not sure if complete tolerance can be achieved at all doses or only lower doses.</p><p></p><p>My fear of triggering major reflux kept me on the small daily shot format during my first few months on TRT. I think that was unnecessary or possibly a mistake now, because I've recently taken a couple of larger bolus doses (30 mg, 45 mg) of cypionate without any worse reflux compared to the same dose as daily shots over the same timeframe. It might even be possible that reflux is mainly worsened when testosterone levels are rising, in which case peaking daily would be worse than less frequent injections. I'm testing this theory now by switching to a vanilla 50 mg twice weekly protocol.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 233483, member: 44064"] I haven't mentioned this previously but I definitely see worsened reflux from TRT. When I first started it was brutal. I suspect the mechanism involves beta adrenergic stimulation: [URL unfurl="true"]https://gut.bmj.com/content/gutjnl/27/3/260.full.pdf[/URL] [ATTACH type="full" alt="beta adrenergic influence on LES.png"]25399[/ATTACH] [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/11591558/[/URL] [USER=38590]@readalot[/USER] is familiar with the effects of TRT on beta adrenergic receptors and might be able to elaborate. I've seen enough complaints of TRT-exaggerated GERD / reflux symptoms on Reddit that I do think it's a real thing. There might be other mechanisms at work also. Higher E2 is associated with GERD in women and has lower esophageal sphincter relaxant effects: [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7689967/[/URL] This exaggeration of reflux by TRT seems worst when I first started and whenever I increase the dose. At least partial tolerance seems to build relatively quickly (within 1-2 weeks). I'm not sure if complete tolerance can be achieved at all doses or only lower doses. My fear of triggering major reflux kept me on the small daily shot format during my first few months on TRT. I think that was unnecessary or possibly a mistake now, because I've recently taken a couple of larger bolus doses (30 mg, 45 mg) of cypionate without any worse reflux compared to the same dose as daily shots over the same timeframe. It might even be possible that reflux is mainly worsened when testosterone levels are rising, in which case peaking daily would be worse than less frequent injections. I'm testing this theory now by switching to a vanilla 50 mg twice weekly protocol. [/QUOTE]
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Acid Reflux and GERD Treatement
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