ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A SERM (fispemifene) increases testosterone but not sex drive
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 35837" data-attributes="member: 3"><p>From <a href="http://www.excelmale.com/store/product/testosterone-a-mans-guide-second-edition-2/" target="_blank">my book</a></p><p></p><p>"Clomiphene citrate is a selective estrogen receptor (ER) modulator approved in 1967 for the treatment of female infertility. It should be noted that most of the data for clomiphene were obtained through studies conducted in women, and good studies with its use in men have yet to be conducted (there is a company setting up research studies to explore the use of clomiphene in men with hypogonadism induced by long term anabolic steroid use). Clomiphene citrate's mechanism of action is primarily as an “antiestrogen.” It occupies estrogen receptors and “deceives” the hypothalamus into sensing a low estrogen environment. This activity enhances the hypothalamus' release of GnRH, which impacts the HPGA by stimulating release of FSH and LH from the pituitary. Clomiphene citrate may provide an approach to hormone replacement that is more similar to the normal physiology of the HPGA compared with testosterone replacement therapy, and it may preserve fertility. However, several studies evaluating clomiphene citrate for the treatment of male infertility have produced mixed results. Further study will be needed to clarify the compound's potential utility in this indication.But can clomiphene improve sexual function in men without the co- current use of testosterone? To answer this question, Dr. Guay and his team</p><p>at the Center for Sexual Function in Peabody, Massachusetts, studied the effect of clomiphene citrate on primary hypogonadism (testicles themselves aren't producing enough testosterone) and erectile dysfunction in 272 men who have never used testosterone. Of these 272 trial participants, 228 completed a four-month regimen of clomiphene citrate dosed at 50 mg three times a week.</p><p></p><p>Mean age of these 173 men was 54<em>.</em>3 years. After four months of treatment, 75<em>.</em>1 percent of subjects reported improvement in erectile dysfunction including 38<em>.</em>7 percent who reported normal sexual function. The other 24<em>.</em>8 percent reported no change in erectile dysfunction. Serum LH and testosterone levels increased significantly compared with baseline values in all groups (responders, partial responders, and non-responders).</p><p></p><p>Importantly, clomiphene citrate did not result in supraphysiologic (higher than normal) levels of testosterone in this study, and testosterone levels were maintained within a normal range. Multivariate analysis revealed that age was the patient characteristic most predictive of positive or partial response to clomiphene citrate, with patients aged 55 years and younger more likely to respond compared with patients aged 56 years or older. Free testosterone blood levels were not reported, so it is difficult to attain why there was a difference in response in older men.</p><p></p><p>For dosing and a protocol that uses clomiphene, HCG and tamoxifen to help to normalize the HPGA after testosterone or anabolic use, please refer to the HPGA dysfunction section and in the Chapter 7 (interview with Dr. Michael Scally).</p><p>More studies are needed using clomiphene citrate alone or in combination with HCG and/or tamoxifen or anastrozole so that doctors feel more comfortable prescribing these compounds to help balance the HPGA.</p><p></p><p>Practical matters to keep in mind: Some men report experiencing mood changes and feel more emotional when using clomiphene citrate. I have not seen any data on Clomiphene's effects on estradiol levels, so it is unknown if this reported mood changes are due to higher estradiol. Clomiphene citrate can be quite expensive, although it can be found at lower prices at compounding pharmacies by prescription. Many doctors do not like to prescribe it due to the limited available data and the fact that it is not approved for men. Some doctors prescribe it off-label and patients pay for it out of their own pockets. It is not a controlled substance under the US Drug Enforcement Agency (DEA). Some men order it for personal use from websites of overseas companies at very low prices."</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 35837, member: 3"] From [URL="http://www.excelmale.com/store/product/testosterone-a-mans-guide-second-edition-2/"]my book[/URL] "Clomiphene citrate is a selective estrogen receptor (ER) modulator approved in 1967 for the treatment of female infertility. It should be noted that most of the data for clomiphene were obtained through studies conducted in women, and good studies with its use in men have yet to be conducted (there is a company setting up research studies to explore the use of clomiphene in men with hypogonadism induced by long term anabolic steroid use). Clomiphene citrate's mechanism of action is primarily as an “antiestrogen.” It occupies estrogen receptors and “deceives” the hypothalamus into sensing a low estrogen environment. This activity enhances the hypothalamus' release of GnRH, which impacts the HPGA by stimulating release of FSH and LH from the pituitary. Clomiphene citrate may provide an approach to hormone replacement that is more similar to the normal physiology of the HPGA compared with testosterone replacement therapy, and it may preserve fertility. However, several studies evaluating clomiphene citrate for the treatment of male infertility have produced mixed results. Further study will be needed to clarify the compound's potential utility in this indication.But can clomiphene improve sexual function in men without the co- current use of testosterone? To answer this question, Dr. Guay and his team at the Center for Sexual Function in Peabody, Massachusetts, studied the effect of clomiphene citrate on primary hypogonadism (testicles themselves aren't producing enough testosterone) and erectile dysfunction in 272 men who have never used testosterone. Of these 272 trial participants, 228 completed a four-month regimen of clomiphene citrate dosed at 50 mg three times a week. Mean age of these 173 men was 54[I].[/I]3 years. After four months of treatment, 75[I].[/I]1 percent of subjects reported improvement in erectile dysfunction including 38[I].[/I]7 percent who reported normal sexual function. The other 24[I].[/I]8 percent reported no change in erectile dysfunction. Serum LH and testosterone levels increased significantly compared with baseline values in all groups (responders, partial responders, and non-responders). Importantly, clomiphene citrate did not result in supraphysiologic (higher than normal) levels of testosterone in this study, and testosterone levels were maintained within a normal range. Multivariate analysis revealed that age was the patient characteristic most predictive of positive or partial response to clomiphene citrate, with patients aged 55 years and younger more likely to respond compared with patients aged 56 years or older. Free testosterone blood levels were not reported, so it is difficult to attain why there was a difference in response in older men. For dosing and a protocol that uses clomiphene, HCG and tamoxifen to help to normalize the HPGA after testosterone or anabolic use, please refer to the HPGA dysfunction section and in the Chapter 7 (interview with Dr. Michael Scally). More studies are needed using clomiphene citrate alone or in combination with HCG and/or tamoxifen or anastrozole so that doctors feel more comfortable prescribing these compounds to help balance the HPGA. Practical matters to keep in mind: Some men report experiencing mood changes and feel more emotional when using clomiphene citrate. I have not seen any data on Clomiphene's effects on estradiol levels, so it is unknown if this reported mood changes are due to higher estradiol. Clomiphene citrate can be quite expensive, although it can be found at lower prices at compounding pharmacies by prescription. Many doctors do not like to prescribe it due to the limited available data and the fact that it is not approved for men. Some doctors prescribe it off-label and patients pay for it out of their own pockets. It is not a controlled substance under the US Drug Enforcement Agency (DEA). Some men order it for personal use from websites of overseas companies at very low prices." [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A SERM (fispemifene) increases testosterone but not sex drive
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top