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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A new oral T (TLANDO) treatment regimen without dose titration requirement for male hypogonadism
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<blockquote data-quote="madman" data-source="post: 216816" data-attributes="member: 13851"><p><em><strong>*Oral administration of non-esterified T generally results in low bioavailability as it is extensively metabolized through first-pass metabolism</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong>Oral administration of TU provides a sufficient TU level by lymphatic route absorption through the gastrointestinal tract avoiding the first-pass metabolism, then TU is converted to T by non-specific esterases abundant in the body, overcoming the low oral bioavailability of native T</strong></em></strong></em></p><p><em><strong><em><strong></strong></em></strong></em></p><p><em><strong><em><strong>*Oral administration of TU appears to avoid the serious hepatic adverse effects and fatal complications observed after oral administration of 17-α-methylated T products</strong></em></strong></em></p><p><em><strong><em><strong></strong></em></strong></em></p><p><em><strong><em><strong>*<em><strong>TLANDO is an oral capsule product having 112.5 mg of TU in a unique lipid formulation containing predominantly predigested triglycerides (mono- or di-glycerides). It was designed to enable absorption of TU via the intestinal lymphatic pathway</strong></em></strong></em></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*mean serum T concentrations were restored to the normal range within 2 h after TLANDO dose administration. Serum T concentrations reached a peak concentration approximately 4–6 h after dosing.</strong> <strong>After that, T concentrations declined and approached pre-dose levels after approximately 12 h post-administration</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 216816, member: 13851"] [I][B]*Oral administration of non-esterified T generally results in low bioavailability as it is extensively metabolized through first-pass metabolism *[I][B]Oral administration of TU provides a sufficient TU level by lymphatic route absorption through the gastrointestinal tract avoiding the first-pass metabolism, then TU is converted to T by non-specific esterases abundant in the body, overcoming the low oral bioavailability of native T *Oral administration of TU appears to avoid the serious hepatic adverse effects and fatal complications observed after oral administration of 17-α-methylated T products *[I][B]TLANDO is an oral capsule product having 112.5 mg of TU in a unique lipid formulation containing predominantly predigested triglycerides (mono- or di-glycerides). It was designed to enable absorption of TU via the intestinal lymphatic pathway[/B][/I][/B][/I] *mean serum T concentrations were restored to the normal range within 2 h after TLANDO dose administration. Serum T concentrations reached a peak concentration approximately 4–6 h after dosing.[/B] [B]After that, T concentrations declined and approached pre-dose levels after approximately 12 h post-administration[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A new oral T (TLANDO) treatment regimen without dose titration requirement for male hypogonadism
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