ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
A fresh look at kisspeptin neuron synchronization
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 243305" data-attributes="member: 13851"><p>[ATTACH=full]28454[/ATTACH]</p><p><strong>The arcuate kisspeptin neuron population in a coronal brain slice. Image courtesy of the Herbison laboratory</strong></p><p></p><p></p><p></p><p></p><p><em>For many years, the ‘KNDy hypothesis’ has been the main mechanistic explanation of the pulsatile secretion of gonadotropin hormones. <strong>New research in Cell Reports proposes an alternative mechanism. </strong></em></p><p><em></em></p><p><em>The arcuate nucleus kisspeptin (ARNKISS) neuronal network is a key part of the pulse generator. The KNDy hypothesis suggests that this network is regulated by an interplay between kisspeptin neurons and two coreleased neurotransmitters (neurokinin B and dynorphin).<strong> In this paper, the researchers used three approaches to investigate the mechanisms by which the ARNKISS neuronal network operates.</strong> </em></p><p><em></em></p><p><em>First, the researchers used GCaMP mini scopes in freely moving male mice to record the activation of each kisspeptin neuron during spontaneous synchronization events.<strong> “Then, to examine the contributions of key neurotransmitters and neuropeptides coreleased by ARNKISS neurons we developed a novel in vitro brain slice preparation,”</strong> explains author Paul Morris.<strong> This approach enabled the researchers to maintain spontaneous synchronizations within the neural network and to assess the effects of a range of receptor antagonists. Finally, the researchers used in vivo GCaMP fiber photometry coupled with microinfusion of the receptor antagonists directly into the ARN.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>“It turns out that the key transmitter enabling the synchronized activity of kisspeptin neurons is the <u>small amino acid transmitter glutamate</u>,”</strong> explains author Su Young Han. Unlike what is predicted by the KNDy hypothesis, <strong>dynorphin controlled the frequency of glutamate-driven synchronization and neurokinin B facilitated the end-stage of synchronization. In addition, neither neurokinin B nor dynorphin was essential for ARNKISS neuron synchronization</strong></em></p><p><em><strong></strong></em></p><p><em><strong>“This study reframes a longheld hypothesis regarding the operation of a key hypothalamic central pattern generator,”</strong> concludes author Allan Herbison.<strong> “The mode of synchronization within the ARNKISS neural network is essential for normal fertility; we, therefore, expect that this significant advance in our understanding of the system will lead to future clinical treatments for infertility.” </strong>The researchers also highlight several areas for future research, such as determining whether the same mechanism is present in female mice and how the synchronization is turned off.</em></p></blockquote><p></p>
[QUOTE="madman, post: 243305, member: 13851"] [ATTACH type="full" alt="Screenshot (19973).png"]28454[/ATTACH] [B]The arcuate kisspeptin neuron population in a coronal brain slice. Image courtesy of the Herbison laboratory[/B] [I]For many years, the ‘KNDy hypothesis’ has been the main mechanistic explanation of the pulsatile secretion of gonadotropin hormones. [B]New research in Cell Reports proposes an alternative mechanism. [/B] The arcuate nucleus kisspeptin (ARNKISS) neuronal network is a key part of the pulse generator. The KNDy hypothesis suggests that this network is regulated by an interplay between kisspeptin neurons and two coreleased neurotransmitters (neurokinin B and dynorphin).[B] In this paper, the researchers used three approaches to investigate the mechanisms by which the ARNKISS neuronal network operates.[/B] First, the researchers used GCaMP mini scopes in freely moving male mice to record the activation of each kisspeptin neuron during spontaneous synchronization events.[B] “Then, to examine the contributions of key neurotransmitters and neuropeptides coreleased by ARNKISS neurons we developed a novel in vitro brain slice preparation,”[/B] explains author Paul Morris.[B] This approach enabled the researchers to maintain spontaneous synchronizations within the neural network and to assess the effects of a range of receptor antagonists. Finally, the researchers used in vivo GCaMP fiber photometry coupled with microinfusion of the receptor antagonists directly into the ARN. “It turns out that the key transmitter enabling the synchronized activity of kisspeptin neurons is the [U]small amino acid transmitter glutamate[/U],”[/B] explains author Su Young Han. Unlike what is predicted by the KNDy hypothesis, [B]dynorphin controlled the frequency of glutamate-driven synchronization and neurokinin B facilitated the end-stage of synchronization. In addition, neither neurokinin B nor dynorphin was essential for ARNKISS neuron synchronization “This study reframes a longheld hypothesis regarding the operation of a key hypothalamic central pattern generator,”[/B] concludes author Allan Herbison.[B] “The mode of synchronization within the ARNKISS neural network is essential for normal fertility; we, therefore, expect that this significant advance in our understanding of the system will lead to future clinical treatments for infertility.” [/B]The researchers also highlight several areas for future research, such as determining whether the same mechanism is present in female mice and how the synchronization is turned off.[/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
A fresh look at kisspeptin neuron synchronization
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top