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General Health & Fitness
Nutrition and Supplements
A Five-Ingredient Nutritional Supplement and (HBRE) Improve Lean Mass and Strength in Free-Living Elderly
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<blockquote data-quote="madman" data-source="post: 184724" data-attributes="member: 13851"><p><strong>Abstract:</strong><em><span style="color: rgb(184, 49, 47)"> Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. </span></em><span style="color: rgb(44, 130, 201)"><em>In this randomized, placebo-controlled, and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men.</em></span> Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with a daily intake of a novel five-nutrient supplement (‘Muscle5’; M5, n = 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; n = 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; −9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post-tests; p < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post-intervention (Type IIa; +30.9%, Type IIx, +28.5%, p < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, p < 0.05). <em><span style="color: rgb(184, 49, 47)">We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.</span></em></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>5. </strong></span><span style="color: rgb(0, 0, 0)"><strong>Conclusions </strong></span></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong><em>Herein, we have demonstrated that once-daily multi-ingredient supplementation with whey, micellar casein, creatine, vitamin D3, EPA/DHA (‘Muscle5’; M5), and home-based, low-intensity resistance exercise (3 d/week), improve total lean mass, muscle fiber size, muscle-to-fat ratios, strength, performance, and overall muscle quality in free-living, physically inactive, older males. </em></strong></span><span style="color: rgb(0, 0, 0)">Previous RCTs have shown that an almost identical blend of nutrients augments muscle gains independently and in conjunction with supervised resistance exercise/HIIT [53], and may confer anti-inflammatory and cognitive benefits in healthy older males [69,70]. Our results also suggest that the M5 supplement may potentiate muscle gains in resistance-trained sarcopenic men, although a larger cohort, including both male and female participants, will be necessary to confirm its clinical relevance. Future studies on muscle, cognitive, and immune benefits in high-risk populations using the current low-dosage M5 iteration are warranted, particularly in women.</span><span style="color: rgb(44, 130, 201)"><em><strong> We conclude that protein-based, multi-ingredient supplementation, such as Muscle5, is safe, well-tolerated, and an effective complement to strength training for maintenance of skeletal muscle in old age.</strong></em></span></p></blockquote><p></p>
[QUOTE="madman, post: 184724, member: 13851"] [B]Abstract:[/B][I][COLOR=rgb(184, 49, 47)] Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. [/COLOR][/I][COLOR=rgb(44, 130, 201)][I]In this randomized, placebo-controlled, and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men.[/I][/COLOR] Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with a daily intake of a novel five-nutrient supplement (‘Muscle5’; M5, n = 16, 77.4 ± 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; n = 16, 74.4 ± 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; −9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post-tests; p < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post-intervention (Type IIa; +30.9%, Type IIx, +28.5%, p < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, p < 0.05). [I][COLOR=rgb(184, 49, 47)]We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.[/COLOR][/I] [COLOR=rgb(184, 49, 47)][B]5. [/B][/COLOR][COLOR=rgb(0, 0, 0)][B]Conclusions [/B][/COLOR] [COLOR=rgb(184, 49, 47)][B][I]Herein, we have demonstrated that once-daily multi-ingredient supplementation with whey, micellar casein, creatine, vitamin D3, EPA/DHA (‘Muscle5’; M5), and home-based, low-intensity resistance exercise (3 d/week), improve total lean mass, muscle fiber size, muscle-to-fat ratios, strength, performance, and overall muscle quality in free-living, physically inactive, older males. [/I][/B][/COLOR][COLOR=rgb(0, 0, 0)]Previous RCTs have shown that an almost identical blend of nutrients augments muscle gains independently and in conjunction with supervised resistance exercise/HIIT [53], and may confer anti-inflammatory and cognitive benefits in healthy older males [69,70]. Our results also suggest that the M5 supplement may potentiate muscle gains in resistance-trained sarcopenic men, although a larger cohort, including both male and female participants, will be necessary to confirm its clinical relevance. Future studies on muscle, cognitive, and immune benefits in high-risk populations using the current low-dosage M5 iteration are warranted, particularly in women.[/COLOR][COLOR=rgb(44, 130, 201)][I][B] We conclude that protein-based, multi-ingredient supplementation, such as Muscle5, is safe, well-tolerated, and an effective complement to strength training for maintenance of skeletal muscle in old age.[/B][/I][/COLOR] [/QUOTE]
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A Five-Ingredient Nutritional Supplement and (HBRE) Improve Lean Mass and Strength in Free-Living Elderly
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