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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
A different dosing strategy with bremelanotide (PT-141) yields dramatically better results
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<blockquote data-quote="electrify" data-source="post: 266339" data-attributes="member: 44439"><p>I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. Had to get ECT. I had symptoms basically resembling that of PSSD/PFS just from using it once. </p><p></p><p>Then I was fine for years until last year, when post covid an alcohol hangover made me relapse into some anhedonia suddenly. And I bet that the PT-141 incident way back somehow made my brain sensitized. I never ever had experienced any anhedonia before it. </p><p></p><p>And interestingly even today, MIF-1 the *opposite* peptide to PT-141 is actually helpful for my anhedonia issues when cycled. </p><p></p><p>I don't think melanocortin agonists are safe for dopamine either: </p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397405/[/URL]</p><p></p><p>"Here we show that chronic stress decreases the strength of excitatory synapses on D1 dopamine receptor-expressing nucleus accumbens medium spiny neurons due to activation of melanocortin 4 receptors (MC4Rs)" </p><p></p><p>So literally PT-141 can *lower* dopamine signaling. </p><p></p><p>On the other hand MIF-1 enhances dopamine:</p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915805/[/URL]</p></blockquote><p></p>
[QUOTE="electrify, post: 266339, member: 44439"] I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. Had to get ECT. I had symptoms basically resembling that of PSSD/PFS just from using it once. Then I was fine for years until last year, when post covid an alcohol hangover made me relapse into some anhedonia suddenly. And I bet that the PT-141 incident way back somehow made my brain sensitized. I never ever had experienced any anhedonia before it. And interestingly even today, MIF-1 the *opposite* peptide to PT-141 is actually helpful for my anhedonia issues when cycled. I don't think melanocortin agonists are safe for dopamine either: [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397405/[/URL] "Here we show that chronic stress decreases the strength of excitatory synapses on D1 dopamine receptor-expressing nucleus accumbens medium spiny neurons due to activation of melanocortin 4 receptors (MC4Rs)" So literally PT-141 can *lower* dopamine signaling. On the other hand MIF-1 enhances dopamine: [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915805/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
A different dosing strategy with bremelanotide (PT-141) yields dramatically better results
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