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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
A different dosing strategy with bremelanotide (PT-141) yields dramatically better results
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<blockquote data-quote="Guided_by_Voices" data-source="post: 265800" data-attributes="member: 15235"><p>Great work! That’s some fantastic citizen-science right there. I think reports like this give us a sense that much more is possible than what is commonly known and that we have only scratched the surface of what can be done. A few comments:</p><p></p><ul> <li data-xf-list-type="ul">Anything that stimulates the sympathetic nervous system is likely to be anti-sexual and the reports of anxiety suggest that may be happening at larger doses.</li> <li data-xf-list-type="ul">From a practical perspective for others who want to try this, I assume you’re transferring the product to a larger vial and diluting it in order to get down to such small doses. This also argues for brewing a nasal delivery option. That was how it was originally envisioned by Palatin, but the nasal delivery apparently caused unacceptable blood pressure spikes, however those might not be present at smaller doses.</li> <li data-xf-list-type="ul">Stimulating the melanocortin system in this way seems like it can be thought of as injectable sunshine so it may not be possible to create a dawn-to-dusk affect without some form of down-regulation.</li> <li data-xf-list-type="ul">While I’m not in the camp that says nature has always done things the best way for our modern situation, nature got it right a very high percentage of the time and most males throughout history would have been hunting and gathering during the day while the nubile females were closer to the campsite, which could explain why the body seems to be optimized for nighttime/early morning sex, and hence why PT-141 seems to work better in that scenario.</li> <li data-xf-list-type="ul">It would be interesting to combine your approach with TNE or other short-acting forms of T, and/or something that mimics a low-epinephrine state (e.g. doxazosin).</li> <li data-xf-list-type="ul"></li> </ul><p>Finally, while I fully support those who have sensibly arrived at an individual benefit from relatively high doses of hormone-related compounds, I think the pathological compulsion to default to high-doses in the body-building world has unfairly tainted some compounds that are considered “harsh” but which might be very net-beneficial at lower doses (and intermittent doses), so there is a lot of experimentation left to be done with both PT-141 other compounds and combinations.</p></blockquote><p></p>
[QUOTE="Guided_by_Voices, post: 265800, member: 15235"] Great work! That’s some fantastic citizen-science right there. I think reports like this give us a sense that much more is possible than what is commonly known and that we have only scratched the surface of what can be done. A few comments: [LIST] [*]Anything that stimulates the sympathetic nervous system is likely to be anti-sexual and the reports of anxiety suggest that may be happening at larger doses. [*]From a practical perspective for others who want to try this, I assume you’re transferring the product to a larger vial and diluting it in order to get down to such small doses. This also argues for brewing a nasal delivery option. That was how it was originally envisioned by Palatin, but the nasal delivery apparently caused unacceptable blood pressure spikes, however those might not be present at smaller doses. [*]Stimulating the melanocortin system in this way seems like it can be thought of as injectable sunshine so it may not be possible to create a dawn-to-dusk affect without some form of down-regulation. [*]While I’m not in the camp that says nature has always done things the best way for our modern situation, nature got it right a very high percentage of the time and most males throughout history would have been hunting and gathering during the day while the nubile females were closer to the campsite, which could explain why the body seems to be optimized for nighttime/early morning sex, and hence why PT-141 seems to work better in that scenario. [*]It would be interesting to combine your approach with TNE or other short-acting forms of T, and/or something that mimics a low-epinephrine state (e.g. doxazosin). [*] [/LIST] Finally, while I fully support those who have sensibly arrived at an individual benefit from relatively high doses of hormone-related compounds, I think the pathological compulsion to default to high-doses in the body-building world has unfairly tainted some compounds that are considered “harsh” but which might be very net-beneficial at lower doses (and intermittent doses), so there is a lot of experimentation left to be done with both PT-141 other compounds and combinations. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
A different dosing strategy with bremelanotide (PT-141) yields dramatically better results
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