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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A body shape index reflects body composition changes in response to TRT in obese men
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<blockquote data-quote="madman" data-source="post: 134397" data-attributes="member: 13851"><p><strong>Abstract</strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Background</span></strong> Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial changes in weight and BMI.</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Objectives </span></strong>Using testosterone treatment as a paradigm, we hypothesized that a body shape index (ABSI) reflects body composition changes more accurately than traditional markers, such as weight, BMI and waist circumference. Intervention Secondary analysis of a 56-week RCT in 100 dieting obese men with low–normal testosterone receiving testosterone treatment or placebo, and subsequent off-treatment follow-up.</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Results </span></strong>At the end of the trial period, ABSI—unlike weight, BMI or waist circumference—had significantly decreased in the treatment group, compared with placebo (mean adjusted difference −0.18 [95% CI: −0.32, −0.05] × 10−2 m11/6kg−2/3, overall P<0.001). Changes in ABSI during the active trial phase correlated with changes in fat mass (tau=0.18, P=0.02), and not with lean mass (tau=−0.11, P=0.14), BMI (tau=0.10, P=0.17), or visceral fat (tau=0.07, P=0.37). ABSI baseline values were positively correlated with waist circumference (tau=0.21, P=0.002) and visceral fat (tau=0.18, P=0.009), correlated inversely with lean mass (tau=−0.21, P=0.002), and were uncorrelated with BMI (tau=−0.10, P=0.15) and fat mass (tau=0.01, P=0.83). Two years after cessation of treatment, ABSI again reflected body composition as the between-group differences in all parameters did not persist.</p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Conclusions</span></strong> A readily obtainable anthropomorphic measure, ABSI reflects the differential loss of fat mass mediated by testosterone in dieting obese men more closely than BMI or waist circumference. It may serve as a clinically useful marker to monitor body composition changes, particularly in response to interventions.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>In conclusion, <strong>a simple and readily available anthropomorphic measure of body shape (ABSI) reflected the differential loss of fat mass observed in dieting obese men and <span style="color: rgb(184, 49, 47)">responded more sensitively to testosterone treatment </span>than other traditional markers of obesity risk, such as weight, BMI, and waist circumference.</strong> It may therefore be clinically useful and warrants further evaluation as a prognostic marker to monitor potentially metabolically relevant changes in body composition in response to more weight and BMI-neutral interventions such as testosterone treatment.</p></blockquote><p></p>
[QUOTE="madman, post: 134397, member: 13851"] [B]Abstract[/B] [B][COLOR=rgb(184, 49, 47)]Background[/COLOR][/B] Interventions such as testosterone treatment may change body composition and metabolic outcomes without substantial changes in weight and BMI. [B][COLOR=rgb(184, 49, 47)]Objectives [/COLOR][/B]Using testosterone treatment as a paradigm, we hypothesized that a body shape index (ABSI) reflects body composition changes more accurately than traditional markers, such as weight, BMI and waist circumference. Intervention Secondary analysis of a 56-week RCT in 100 dieting obese men with low–normal testosterone receiving testosterone treatment or placebo, and subsequent off-treatment follow-up. [B][COLOR=rgb(184, 49, 47)]Results [/COLOR][/B]At the end of the trial period, ABSI—unlike weight, BMI or waist circumference—had significantly decreased in the treatment group, compared with placebo (mean adjusted difference −0.18 [95% CI: −0.32, −0.05] × 10−2 m11/6kg−2/3, overall P<0.001). Changes in ABSI during the active trial phase correlated with changes in fat mass (tau=0.18, P=0.02), and not with lean mass (tau=−0.11, P=0.14), BMI (tau=0.10, P=0.17), or visceral fat (tau=0.07, P=0.37). ABSI baseline values were positively correlated with waist circumference (tau=0.21, P=0.002) and visceral fat (tau=0.18, P=0.009), correlated inversely with lean mass (tau=−0.21, P=0.002), and were uncorrelated with BMI (tau=−0.10, P=0.15) and fat mass (tau=0.01, P=0.83). Two years after cessation of treatment, ABSI again reflected body composition as the between-group differences in all parameters did not persist. [B][COLOR=rgb(184, 49, 47)]Conclusions[/COLOR][/B] A readily obtainable anthropomorphic measure, ABSI reflects the differential loss of fat mass mediated by testosterone in dieting obese men more closely than BMI or waist circumference. It may serve as a clinically useful marker to monitor body composition changes, particularly in response to interventions. In conclusion, [B]a simple and readily available anthropomorphic measure of body shape (ABSI) reflected the differential loss of fat mass observed in dieting obese men and [COLOR=rgb(184, 49, 47)]responded more sensitively to testosterone treatment [/COLOR]than other traditional markers of obesity risk, such as weight, BMI, and waist circumference.[/B] It may therefore be clinically useful and warrants further evaluation as a prognostic marker to monitor potentially metabolically relevant changes in body composition in response to more weight and BMI-neutral interventions such as testosterone treatment. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
A body shape index reflects body composition changes in response to TRT in obese men
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