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6 weeks on TRT - Is there a Honeymoon Phase or Too high a Dose Perhaps ???
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<blockquote data-quote="Cataceous" data-source="post: 250285" data-attributes="member: 38109"><p>Nothing very specific about PT-141. A quick guesstimate suggests that receptors are being activated by at least an order of magnitude more than usual. Anything that non-physiological makes me uneasy. I experienced some long-lasting functional problems after trying it a few times, though I'll be the first to acknowledge that they could be unrelated.</p><p></p><p></p><p>The high testosterone has crashed your SHBG. Contrary to popular belief, falling SHBG has little, if any effect on free testosterone and free estradiol; these are governed by the dose rate. However, low SHBG does suppress total testosterone. Though speculative, it's possible that low SHBG reduces androgenic signaling relative to estrogenic signaling, leading to the estrogenic side effects. For free testosterone, I would target 13-15 ng/dL, mid-range for young guys in the Vermeulen calculated free T scale. This should help with recovery of SHBG.</p><p></p><p>Reiterating, research suggests that there is a threshold effect for testosterone when it comes to libido and sexual function. When testosterone is below the individual's threshold these can be impaired. But once you're over the threshold there are not additional improvements to be had by raising testosterone more. The threshold is not that high. For most guys it's going to occur with free testosterone in the range of 10-15 ng/dL.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 250285, member: 38109"] Nothing very specific about PT-141. A quick guesstimate suggests that receptors are being activated by at least an order of magnitude more than usual. Anything that non-physiological makes me uneasy. I experienced some long-lasting functional problems after trying it a few times, though I'll be the first to acknowledge that they could be unrelated. The high testosterone has crashed your SHBG. Contrary to popular belief, falling SHBG has little, if any effect on free testosterone and free estradiol; these are governed by the dose rate. However, low SHBG does suppress total testosterone. Though speculative, it's possible that low SHBG reduces androgenic signaling relative to estrogenic signaling, leading to the estrogenic side effects. For free testosterone, I would target 13-15 ng/dL, mid-range for young guys in the Vermeulen calculated free T scale. This should help with recovery of SHBG. Reiterating, research suggests that there is a threshold effect for testosterone when it comes to libido and sexual function. When testosterone is below the individual's threshold these can be impaired. But once you're over the threshold there are not additional improvements to be had by raising testosterone more. The threshold is not that high. For most guys it's going to occur with free testosterone in the range of 10-15 ng/dL. [/QUOTE]
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6 weeks on TRT - Is there a Honeymoon Phase or Too high a Dose Perhaps ???
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