Reply to thread

It's always comical on this forum when they claim that TRT solves all sexual problems. In reality, TRT resolves problems only when they were due to really low T before TRT, but many people get on TRT to "enhance" themselves, not because they actually had low T.


Testosterone is a weak manipulator of dopamine/libido. For example, TRT boosts libido typically during the initial honeymoon period but then the negative feedback kicks in, dopamine receptors downregulate, and libido goes back to zero.


If you want to enhance libido, it's more sensible to look into direct dopaminergic drugs, like the Amantadine study that I cited. Testosterone is a secondary drug and quite ineffective at manipulating dopamine, unless it was really low before TRT, causing low dopamine, in which case restoring the normal testosterone levels restores dopamine and libido.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Back
Top