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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
42 y/o, scrotal cream, high dht and acne... will finasteride help?
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<blockquote data-quote="Cataceous" data-source="post: 214091" data-attributes="member: 38109"><p>The problems with finasteride go beyond reductions in DHT. The 5ar enzyme also converts progesterone into dihydroprogesterone, an intermediate in the path to allopregnanolone.</p><p></p><p style="margin-left: 20px"><em>... While the mechanisms of the sexual side-effects in humans is incompletely understood, one study found lower cerebrospinal fluid concentrations of dihydrotestosterone, progesterone, dihydroprogesterone and allopregnanolone, and higher levels of testosterone, 5α-androstane-3α,17β-diol and pregnenolone. Another study found up-regulation of the androgen receptor in the human foreskin with a mean of 5 years after finasteride discontinuation. Studies of erectile dysfunction in finasteride-treated rats showed fewer autophagosomes in smooth muscle on transmission electron microscopy, increased apoptosis, decreased smooth muscle, increased collagen deposition and decreased endothelial nitric oxide synthase. Finally, 5α reductase inhibitors have also been found to alter semen parameters in healthy men.</em></p> <p style="margin-left: 20px">[<a href="https://pubmed.ncbi.nlm.nih.gov/25871957/" target="_blank">R</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214091, member: 38109"] The problems with finasteride go beyond reductions in DHT. The 5ar enzyme also converts progesterone into dihydroprogesterone, an intermediate in the path to allopregnanolone. [INDENT][I]... While the mechanisms of the sexual side-effects in humans is incompletely understood, one study found lower cerebrospinal fluid concentrations of dihydrotestosterone, progesterone, dihydroprogesterone and allopregnanolone, and higher levels of testosterone, 5α-androstane-3α,17β-diol and pregnenolone. Another study found up-regulation of the androgen receptor in the human foreskin with a mean of 5 years after finasteride discontinuation. Studies of erectile dysfunction in finasteride-treated rats showed fewer autophagosomes in smooth muscle on transmission electron microscopy, increased apoptosis, decreased smooth muscle, increased collagen deposition and decreased endothelial nitric oxide synthase. Finally, 5α reductase inhibitors have also been found to alter semen parameters in healthy men.[/I][/INDENT] [INDENT][[URL='https://pubmed.ncbi.nlm.nih.gov/25871957/']R[/URL]][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
42 y/o, scrotal cream, high dht and acne... will finasteride help?
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