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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
40 % of Men With Brain Injury Have Low Testosterone After A Year of Injury.
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<blockquote data-quote="Nelson Vergel" data-source="post: 24376" data-attributes="member: 3"><p>J Head Trauma Rehabil. 2015 Sep 10. </p><p></p><p>Persistent Hypogonadotropic Hypogonadism in Men After Severe Traumatic Brain Injury: Temporal Hormone Profiles and Outcome Prediction.</p><p></p><p>Barton DJ1, Kumar RG, McCullough EH, Galang G, Arenth PM, Berga SL, Wagner AK.</p><p></p><p></p><p>Abstract</p><p></p><p>OBJECTIVE:</p><p>To (1) examine relationships between persistent hypogonadotropic hypogonadism (PHH) and long-term outcomes after severe traumatic brain injury (TBI); and (2) determine whether subacute testosterone levels can predict PHH.</p><p></p><p>SETTING:</p><p>Level 1 trauma center at a university hospital.</p><p></p><p>PARTICIPANTS:</p><p>Consecutive sample of men with severe TBI between 2004 and 2009.</p><p></p><p>DESIGN:</p><p>Prospective cohort study.</p><p></p><p>MAIN MEASURES:</p><p>Post-TBI blood samples were collected during week 1, every 2 weeks until 26 weeks, and at 52 weeks. Serum hormone levels were measured, and individuals were designated as having PHH if 50% or more of samples met criteria for hypogonadotropic hypogonadism. At 6 and 12 months postinjury, we assessed global outcome, disability, functional cognition, depression, and quality of life.</p><p></p><p>RESULTS:</p><p>We recruited 78 men; median (interquartile range) age was 28.5 (22-42) years. Thirty-four patients (44%) had PHH during the first year post injury. Multivariable regression, controlling for age, demonstrated PHH status predicted worse global outcome scores, more disability, and reduced functional cognition at 6 and 12 months post-TBI. Two-step testosterone screening for PHH at 12 to 16 weeks post injury yielded a sensitivity of 79% and specificity of 100%.</p><p></p><p>CONCLUSION:</p><p>PHH status in men predicts poor outcome after severe TBI, and PHH can accurately be predicted at 12 to 16 weeks.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 24376, member: 3"] J Head Trauma Rehabil. 2015 Sep 10. Persistent Hypogonadotropic Hypogonadism in Men After Severe Traumatic Brain Injury: Temporal Hormone Profiles and Outcome Prediction. Barton DJ1, Kumar RG, McCullough EH, Galang G, Arenth PM, Berga SL, Wagner AK. Abstract OBJECTIVE: To (1) examine relationships between persistent hypogonadotropic hypogonadism (PHH) and long-term outcomes after severe traumatic brain injury (TBI); and (2) determine whether subacute testosterone levels can predict PHH. SETTING: Level 1 trauma center at a university hospital. PARTICIPANTS: Consecutive sample of men with severe TBI between 2004 and 2009. DESIGN: Prospective cohort study. MAIN MEASURES: Post-TBI blood samples were collected during week 1, every 2 weeks until 26 weeks, and at 52 weeks. Serum hormone levels were measured, and individuals were designated as having PHH if 50% or more of samples met criteria for hypogonadotropic hypogonadism. At 6 and 12 months postinjury, we assessed global outcome, disability, functional cognition, depression, and quality of life. RESULTS: We recruited 78 men; median (interquartile range) age was 28.5 (22-42) years. Thirty-four patients (44%) had PHH during the first year post injury. Multivariable regression, controlling for age, demonstrated PHH status predicted worse global outcome scores, more disability, and reduced functional cognition at 6 and 12 months post-TBI. Two-step testosterone screening for PHH at 12 to 16 weeks post injury yielded a sensitivity of 79% and specificity of 100%. CONCLUSION: PHH status in men predicts poor outcome after severe TBI, and PHH can accurately be predicted at 12 to 16 weeks. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
40 % of Men With Brain Injury Have Low Testosterone After A Year of Injury.
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