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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
2 years of insomnia on Test C- various dosages
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<blockquote data-quote="madman" data-source="post: 255971" data-attributes="member: 13851"><p>Natty endogenous T levels of a healthy young male start rising gradually throughout the night reaching a peak in the early AM.</p><p></p><p>Any esterified T even prop will have T levels rising much faster.</p><p></p><p>T levels will start rising within the first 2 hrs post-injection.</p><p></p><p>The closest one would get to mimicking the TT circadian rhythm of a healthy young male would be the Androderm transdermal T-patch (late evening application)!</p><p></p><p></p><p><strong><em>*<u>TT 24 h pattern</u>; moreover, all but one of them differs either somewhat or greatly from the normative one of diurnally active young adult males, which is defined by:</em></strong> <strong><em>(i) <u>elevated and near peak TT level during nighttime sleep</u>, (ii) <u>peak TT level around the time of morning awakening</u>, (iii) <u>moderately elevated TT level during the initial hours of wakefulness</u>, (iv) <u>reduced TT level in the late afternoon, and</u> (v) <u>lowest TT level in the evening</u></em></strong></p><p></p><p>*<em><strong>Consequently, <u>T production occurs in the greatest amount during sleep</u> as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males</strong></em></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/does-patient-applied-trt-pose-risk-for-blood-pressure-elevation.26423/[/URL]</p><p></p><p><strong>Normal Adult Male Testosterone Circadian Rhythm</strong></p><p></p><p><em>T synthesis takes place in the Leydig cells of the testes through LH stimulation. LH is secreted by the pituitary gland into the peripheral circulation in pulses in response to pulses of gonadotropin-releasing hormone (GnRH) emanating from the hypothalamus.<strong> LH pulses exhibit 24 h temporal patterning; they occur in greater number and higher amplitude during the sleep than wake span, suggesting the involvement of sleep-facilitating or sleep-dependent processes (10, 17, 57, 164, 175–177). Consequently, T production occurs in the greatest amount during sleep as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males (91). </strong>T and its aromatized product estradiol, through negative feedback to the hypothalamus-pituitary axis, induce acute LH suppression and thus reduced T production. In response to the subsequently attenuated serum T concentration, GnRH and LH are again expressed in a pulsatile manner to induce pulsatile androgen hormone synthesis (28, 41, 123, 144).</em></p><p><em></em></p><p><em></em></p><p><em>Figures 2A-2F depict the TT 24 h pattern achieved by the 6 different solution and gel PA-TRTs, and Figures 3A-3D depict the TT 24 h pattern achieved by the buccal tablet, oral capsule, transdermal patch, and subcutaneously injected PATRTs. <strong>There are substantial differences between the therapies in the derived TT 24 h pattern; moreover, all but one of them differs either somewhat or greatly from the normative one of diurnally active young adult males, which is defined by:</strong> <strong>(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, <u>closely mimics the TT circadian rhythm of normal young adult males</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The TT concentration produced by the Androderm® transdermal patch applied to the skin of the back, stomach, upper arms, or thighs <u>nightly before retiring to sleep more closely reproduces the normative TT circadian pattern of young adult males than any of the other marketed PA-TRTs</u>. Following application, TT concentration progressively rises during sleep and peaks around the time of morning awakening; it progressively declines during late morning and afternoon, reaching its nadir (Cmin) in the evening before the next scheduled patch application (Figure 3D)</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 255971, member: 13851"] Natty endogenous T levels of a healthy young male start rising gradually throughout the night reaching a peak in the early AM. Any esterified T even prop will have T levels rising much faster. T levels will start rising within the first 2 hrs post-injection. The closest one would get to mimicking the TT circadian rhythm of a healthy young male would be the Androderm transdermal T-patch (late evening application)! [B][I]*[U]TT 24 h pattern[/U]; moreover, all but one of them differs either somewhat or greatly from the normative one of diurnally active young adult males, which is defined by:[/I][/B] [B][I](i) [U]elevated and near peak TT level during nighttime sleep[/U], (ii) [U]peak TT level around the time of morning awakening[/U], (iii) [U]moderately elevated TT level during the initial hours of wakefulness[/U], (iv) [U]reduced TT level in the late afternoon, and[/U] (v) [U]lowest TT level in the evening[/U][/I][/B] *[I][B]Consequently, [U]T production occurs in the greatest amount during sleep[/U] as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males[/B][/I] [URL unfurl="true"]https://www.excelmale.com/forum/threads/does-patient-applied-trt-pose-risk-for-blood-pressure-elevation.26423/[/URL] [B]Normal Adult Male Testosterone Circadian Rhythm[/B] [I]T synthesis takes place in the Leydig cells of the testes through LH stimulation. LH is secreted by the pituitary gland into the peripheral circulation in pulses in response to pulses of gonadotropin-releasing hormone (GnRH) emanating from the hypothalamus.[B] LH pulses exhibit 24 h temporal patterning; they occur in greater number and higher amplitude during the sleep than wake span, suggesting the involvement of sleep-facilitating or sleep-dependent processes (10, 17, 57, 164, 175–177). Consequently, T production occurs in the greatest amount during sleep as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males (91). [/B]T and its aromatized product estradiol, through negative feedback to the hypothalamus-pituitary axis, induce acute LH suppression and thus reduced T production. In response to the subsequently attenuated serum T concentration, GnRH and LH are again expressed in a pulsatile manner to induce pulsatile androgen hormone synthesis (28, 41, 123, 144). Figures 2A-2F depict the TT 24 h pattern achieved by the 6 different solution and gel PA-TRTs, and Figures 3A-3D depict the TT 24 h pattern achieved by the buccal tablet, oral capsule, transdermal patch, and subcutaneously injected PATRTs. [B]There are substantial differences between the therapies in the derived TT 24 h pattern; moreover, all but one of them differs either somewhat or greatly from the normative one of diurnally active young adult males, which is defined by:[/B] [B](i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. *Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, [U]closely mimics the TT circadian rhythm of normal young adult males[/U] *The TT concentration produced by the Androderm® transdermal patch applied to the skin of the back, stomach, upper arms, or thighs [U]nightly before retiring to sleep more closely reproduces the normative TT circadian pattern of young adult males than any of the other marketed PA-TRTs[/U]. Following application, TT concentration progressively rises during sleep and peaks around the time of morning awakening; it progressively declines during late morning and afternoon, reaching its nadir (Cmin) in the evening before the next scheduled patch application (Figure 3D)[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
2 years of insomnia on Test C- various dosages
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