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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
2 Months on Clomid and ZERO libido
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<blockquote data-quote="AbsoluteZ3R0" data-source="post: 79772" data-attributes="member: 15174"><p>Even if estradiol is managed on clomid, the issue with it is that it behaves agonistically/antagnostically in various E2 receptors throughout the body. Some of these mechanisms are clearly understood, such as that clomid is antagonistic in the hypothalamus, but other mechanisms are not well-known. As a result, it's extremely difficult to nail an effective dose. Since your T was so low to begin with, it's hard to say how much you can really afford to lower the dose while retaining efficacy. What I will say is that I have done as much as 25mg ED, and within 8 days I felt horrible. I cut down to 25mg EOD, but it was still too much. My E2 on the Quest ultra-sensitive was 59pg/mL on 25mg, EOD. If I ever had to go back on clomid, I would run only 12.5 mg every other day. That said, clomid is king when it comes to fertility. HCG works as well, but a combination of HCG and clomid may be the best approach in the short-run if fertility is the prime concern. Estrogen management will definitely be an issue. Over time HCG will cause shutdown akin to trt, but before doing so it can work synergistically with clomid to boost fertility. I know you are considering one or the other, but I think both is best for your purposes. With proper estrogen management, libido can be optimized. If it is still a problem, you may just have to force yourself to ejaculate, even if you can't really perform.</p></blockquote><p></p>
[QUOTE="AbsoluteZ3R0, post: 79772, member: 15174"] Even if estradiol is managed on clomid, the issue with it is that it behaves agonistically/antagnostically in various E2 receptors throughout the body. Some of these mechanisms are clearly understood, such as that clomid is antagonistic in the hypothalamus, but other mechanisms are not well-known. As a result, it's extremely difficult to nail an effective dose. Since your T was so low to begin with, it's hard to say how much you can really afford to lower the dose while retaining efficacy. What I will say is that I have done as much as 25mg ED, and within 8 days I felt horrible. I cut down to 25mg EOD, but it was still too much. My E2 on the Quest ultra-sensitive was 59pg/mL on 25mg, EOD. If I ever had to go back on clomid, I would run only 12.5 mg every other day. That said, clomid is king when it comes to fertility. HCG works as well, but a combination of HCG and clomid may be the best approach in the short-run if fertility is the prime concern. Estrogen management will definitely be an issue. Over time HCG will cause shutdown akin to trt, but before doing so it can work synergistically with clomid to boost fertility. I know you are considering one or the other, but I think both is best for your purposes. With proper estrogen management, libido can be optimized. If it is still a problem, you may just have to force yourself to ejaculate, even if you can't really perform. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
2 Months on Clomid and ZERO libido
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