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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
13 % of Axiron Gets Transferred to Shirts
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<blockquote data-quote="Nelson Vergel" data-source="post: 31654" data-attributes="member: 3"><p>Satonin DK, Ni X, Mitchell MI, Joly H, Muram D, Small DS.<strong></strong></p><p><strong></strong></p><p> <strong>Amount of Testosterone on Laundered Clothing After Use of Testosterone Topical 2% Solution by Healthy Male Volunteers. </strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>J Sex Med. <a href="http://www.jsm.jsexmed.org/article/S1743-6095(15)00023-5/abstract" target="_blank">http://www.jsm.jsexmed.org/article/S1743-6095(15)00023-5/abstract</a> </strong></p><p></p><p></p><p>INTRODUCTION: Testosterone 2% solution (Axiron) applied to armpit(s) is used for replacement therapy in men with a deficiency of endogenous testosterone.</p><p></p><p></p><p>AIM: To determine the amount of testosterone on subjects' T-shirts 12 hours after applying testosterone solution, the residual testosterone on subjects' T-shirts after laundering, and the testosterone transferred to unworn textile items during laundering with worn T-shirts.</p><p></p><p></p><p>METHODS: Healthy males >/=18 years old applied 2 x 1.5 mL of testosterone 2% solution to both axillae (total testosterone dose: 120 mg) and dressed in cotton long-sleeved T-shirts after a >/=3-minute waiting period. T-shirts were worn 12 hours before being removed and cut into halves, after which a 10 x 10 cm sample of each armpit area was excised for testosterone quantification before or after laundering with samples of unworn textiles.</p><p></p><p></p><p>MAIN OUTCOME MEASURES: Testosterone on worn T-shirts before and after laundering, and on unworn textiles laundered with the worn T-shirts.</p><p></p><p></p><p>RESULTS: Twelve subjects enrolled and completed, with only minor adverse events. Mean testosterone in unwashed worn T-shirts was 7603 mug, with high between-subject variability (3359 mug to 13,069 mug), representing 13% of the dose to 1 armpit. Mean testosterone in worn, laundered T-shirts was 260 mug (7.55 mug to 1343 mug), representing 3% of the dose to 1 armpit. Mean transferred testosterone to other textiles during laundering ranged from 69 mug on texturized Dacron 56T Double to 10,402 mug on 87/13 nylon/Lycra knit, representing 0.0382% to 5.78% of the dose to 1 armpit.</p><p></p><p></p><p>CONCLUSION: Thirteen percent of the testosterone applied to axillae was transferred to T-shirts during wear. Ninety-seven percent of the transferred testosterone was removed from the T-shirts during washing, some of which was then absorbed to various degrees by other textiles. Clinical implications of these findings and biological activity of the remaining/transferred testosterone are unknown.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 31654, member: 3"] Satonin DK, Ni X, Mitchell MI, Joly H, Muram D, Small DS.[B] Amount of Testosterone on Laundered Clothing After Use of Testosterone Topical 2% Solution by Healthy Male Volunteers. J Sex Med. [URL]http://www.jsm.jsexmed.org/article/S1743-6095(15)00023-5/abstract[/URL] [/B] INTRODUCTION: Testosterone 2% solution (Axiron) applied to armpit(s) is used for replacement therapy in men with a deficiency of endogenous testosterone. AIM: To determine the amount of testosterone on subjects' T-shirts 12 hours after applying testosterone solution, the residual testosterone on subjects' T-shirts after laundering, and the testosterone transferred to unworn textile items during laundering with worn T-shirts. METHODS: Healthy males >/=18 years old applied 2 x 1.5 mL of testosterone 2% solution to both axillae (total testosterone dose: 120 mg) and dressed in cotton long-sleeved T-shirts after a >/=3-minute waiting period. T-shirts were worn 12 hours before being removed and cut into halves, after which a 10 x 10 cm sample of each armpit area was excised for testosterone quantification before or after laundering with samples of unworn textiles. MAIN OUTCOME MEASURES: Testosterone on worn T-shirts before and after laundering, and on unworn textiles laundered with the worn T-shirts. RESULTS: Twelve subjects enrolled and completed, with only minor adverse events. Mean testosterone in unwashed worn T-shirts was 7603 mug, with high between-subject variability (3359 mug to 13,069 mug), representing 13% of the dose to 1 armpit. Mean testosterone in worn, laundered T-shirts was 260 mug (7.55 mug to 1343 mug), representing 3% of the dose to 1 armpit. Mean transferred testosterone to other textiles during laundering ranged from 69 mug on texturized Dacron 56T Double to 10,402 mug on 87/13 nylon/Lycra knit, representing 0.0382% to 5.78% of the dose to 1 armpit. CONCLUSION: Thirteen percent of the testosterone applied to axillae was transferred to T-shirts during wear. Ninety-seven percent of the transferred testosterone was removed from the T-shirts during washing, some of which was then absorbed to various degrees by other textiles. Clinical implications of these findings and biological activity of the remaining/transferred testosterone are unknown. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
13 % of Axiron Gets Transferred to Shirts
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