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General Health & Fitness
Nutrition and Supplements
1 Mineral for Everything: Magnesium
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<blockquote data-quote="Vince" data-source="post: 216774" data-attributes="member: 843"><p><strong>Magnesium Intake Is Inversely Associated With Coronary Artery Calcification:</strong></p><p><strong>The Framingham Heart Study</strong></p><p>doi:10.1016/j.jcmg.2013.10.006</p><p></p><p>The subtitle tells us, unsurprisingly, that the data set is based on those SADsacks in the FHS, and the dietary details were reliant on the ever-iffy FFQs (as is FHS itself). Mg intake was largely based on FFQ-reported food, plus reported supplement use (but that didn’t drill down to compound forms, and retail Mg supps range from absorbed mineral forms to frank laxatives).</p><p></p><p>What was tested (and in the FHS archival data) was serum Mg, and not RBC-Mg.</p><p></p><p>Perhaps of interest:</p><p>“<em>… each participant underwent 8-slice MDCT scanning consisting of 2 chest scans and 1 abdominal scan (Lightspeed Ultra, General Electric Medical Systems, Milwaukee, Wisconsin) during a single end-inspiratory breath-hold. For CAC, 48 contiguous 2.5-mm-thick slices were acquired in each scan.</em>”</p><p></p><p>They had this data, but didn’t report the details in the paper:</p><p>“<em>Models were adjusted for age, sex, body mass index, smoking status, systolic blood pressure, fasting insulin, total-to-high-density lipoprotein cholesterol ratio, use of hormone replacement therapy (women only), menopausal status (women only), treatment for hyperlipidemia, hypertension, cardiovascular disease prevention, or diabetes, as well as self-reported intake of calcium, vitamins D and K, saturated fat, fiber, alcohol, and energy.</em>”</p><p></p><p>So what was an "extreme" Mg intake?</p><p>“<em>We excluded participants from this analysis if they had missing or uninterpretable CT scans (n = 278); had clinically apparent CVD (n = 136), defined as CABG, valve replacement, percutaneous coronary stent placement, pacemaker, stroke, CHF, MI, or coronary insufficiency identified or occurring prior to the date of the clinic exam (35); had missing or invalid dietary information (n = 172, reporting <600 or ≥4,000 kcal/day for women, <600 or ≥4,200 kcal/day for men, or with ≥12 blank items); self-reported extreme values of magnesium or calcium intake (n = 48, with intake values in the 0.5th or 99.5th percentile); or were missing complete covariate information (n = 200, as defined subsequently). After exclusions, 2,695 participants remained in the present analyses.</em>”</p></blockquote><p></p>
[QUOTE="Vince, post: 216774, member: 843"] [B]Magnesium Intake Is Inversely Associated With Coronary Artery Calcification: The Framingham Heart Study[/B] doi:10.1016/j.jcmg.2013.10.006 The subtitle tells us, unsurprisingly, that the data set is based on those SADsacks in the FHS, and the dietary details were reliant on the ever-iffy FFQs (as is FHS itself). Mg intake was largely based on FFQ-reported food, plus reported supplement use (but that didn’t drill down to compound forms, and retail Mg supps range from absorbed mineral forms to frank laxatives). What was tested (and in the FHS archival data) was serum Mg, and not RBC-Mg. Perhaps of interest: “[I]… each participant underwent 8-slice MDCT scanning consisting of 2 chest scans and 1 abdominal scan (Lightspeed Ultra, General Electric Medical Systems, Milwaukee, Wisconsin) during a single end-inspiratory breath-hold. For CAC, 48 contiguous 2.5-mm-thick slices were acquired in each scan.[/I]” They had this data, but didn’t report the details in the paper: “[I]Models were adjusted for age, sex, body mass index, smoking status, systolic blood pressure, fasting insulin, total-to-high-density lipoprotein cholesterol ratio, use of hormone replacement therapy (women only), menopausal status (women only), treatment for hyperlipidemia, hypertension, cardiovascular disease prevention, or diabetes, as well as self-reported intake of calcium, vitamins D and K, saturated fat, fiber, alcohol, and energy.[/I]” So what was an "extreme" Mg intake? “[I]We excluded participants from this analysis if they had missing or uninterpretable CT scans (n = 278); had clinically apparent CVD (n = 136), defined as CABG, valve replacement, percutaneous coronary stent placement, pacemaker, stroke, CHF, MI, or coronary insufficiency identified or occurring prior to the date of the clinic exam (35); had missing or invalid dietary information (n = 172, reporting <600 or ≥4,000 kcal/day for women, <600 or ≥4,200 kcal/day for men, or with ≥12 blank items); self-reported extreme values of magnesium or calcium intake (n = 48, with intake values in the 0.5th or 99.5th percentile); or were missing complete covariate information (n = 200, as defined subsequently). After exclusions, 2,695 participants remained in the present analyses.[/I]” [/QUOTE]
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1 Mineral for Everything: Magnesium
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