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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
“High-Normal T”
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<blockquote data-quote="Cataceous" data-source="post: 249769" data-attributes="member: 38109"><p>You need to make a distinction between primary and secondary dysfunction. Testosterone interacts with a lot of hormones and systems, so hypogonadism can potentially lead to widespread secondary issues. However, I don't see that hypogonadism is necessarily tied to other primary dysfunction. When I was hypogonadal I was otherwise healthy except for the issues arising from the low testosterone.</p><p></p><p></p><p>That's an interesting twist on an old—and unsupported—argument. Can you cite some published research that takes it beyond speculation? Again, why does the dysfunction have to be system-wide, as opposed to a focal issue at the hypothalamus or pituitary—assuming secondary hypogonadism? I trust you'll exempt primary hypogonadism.</p><p></p><p></p><p>If no evidence is required then I can say with equal certainty that the testosterone level of a man on TRT should be what it was when he was healthy, because that is the level that best integrates with his other hormones. There's the potential to upset various balances when you go above or below what's natural for you. So far I've seen no evidence that natural set points shift permanently after a bout of hypogonadism.</p><p></p><p></p><p>Or not. Testosterone is not the fountain of youth.</p><p></p><p style="margin-left: 20px"><em>Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants...</em></p><p></p><p>"Thyroid hormone resistance syndrome is rare, incidence is variously quoted as <strong>1 in 50,000 or 1 in 40,000 live births</strong>.<a href="https://en.wikipedia.org/wiki/Thyroid_hormone_resistance#cite_note-pmid14517508-9" target="_blank">[9]</a>"[<a href="https://en.wikipedia.org/wiki/Thyroid_hormone_resistance" target="_blank">R</a>]</p><p></p><p>Relevance to the average guy on TRT?</p><p></p><p></p><p>Going by the Vermeulen method, if your SHBG were lowered to a more typical 30 nMol/L then your total testosterone would be an unremarkable 635 ng/dL. Now admittedly Vermeulen might be underestimating your FT at this SHBG, but the general principle stands.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 249769, member: 38109"] You need to make a distinction between primary and secondary dysfunction. Testosterone interacts with a lot of hormones and systems, so hypogonadism can potentially lead to widespread secondary issues. However, I don't see that hypogonadism is necessarily tied to other primary dysfunction. When I was hypogonadal I was otherwise healthy except for the issues arising from the low testosterone. That's an interesting twist on an old—and unsupported—argument. Can you cite some published research that takes it beyond speculation? Again, why does the dysfunction have to be system-wide, as opposed to a focal issue at the hypothalamus or pituitary—assuming secondary hypogonadism? I trust you'll exempt primary hypogonadism. If no evidence is required then I can say with equal certainty that the testosterone level of a man on TRT should be what it was when he was healthy, because that is the level that best integrates with his other hormones. There's the potential to upset various balances when you go above or below what's natural for you. So far I've seen no evidence that natural set points shift permanently after a bout of hypogonadism. Or not. Testosterone is not the fountain of youth. [INDENT][I]Pituitary resistance to thyroid hormone syndrome is associated with T3 receptor mutants...[/I][/INDENT] "Thyroid hormone resistance syndrome is rare, incidence is variously quoted as [B]1 in 50,000 or 1 in 40,000 live births[/B].[URL='https://en.wikipedia.org/wiki/Thyroid_hormone_resistance#cite_note-pmid14517508-9'][9][/URL]"[[URL='https://en.wikipedia.org/wiki/Thyroid_hormone_resistance']R[/URL]] Relevance to the average guy on TRT? Going by the Vermeulen method, if your SHBG were lowered to a more typical 30 nMol/L then your total testosterone would be an unremarkable 635 ng/dL. Now admittedly Vermeulen might be underestimating your FT at this SHBG, but the general principle stands. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
“High-Normal T”
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