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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
“High-Normal T”
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<blockquote data-quote="Cataceous" data-source="post: 249644" data-attributes="member: 38109"><p>That's probably the data I was thinking of, with the range for Vermeulen free testosterone being 7-23 ng/dL, and the average about 14.</p><p></p><p>My cautionary words are intended more for the broader audience, and we are on the same page with respect to low-and-slow on the TRT dosing. You have a lot of experience and know your own body much better than most. I don't presume to know what's best for you. I also don't in general object to guys experimenting with upper-normal levels if they have thoroughly evaluated normal and ideally lower-normal levels first.</p><p></p><p></p><p>I'm wondering how often such cases receive a thorough investigation. And how common are they? What are the "T" symptoms, and how can we be sure they are exclusive to testosterone? A more prosaic problem than excessive CAG repeats or hyper-metabolizing would be an imbalance of androgenic and estrogenic activity. In this case there's a hypothesis linked to the TOT crowd, which is that the ratio of androgenic to estrogenic activity can be increased by pushing testosterone above what's physiological. The aromatase enzyme starts to saturate, reducing the incremental increases in estradiol. Then you get into the argument over whether high-doses of testosterone are better than micro-doses of an aromatase inhibitor.</p><p></p><p></p><p>I don't want to give any false hope, because there are a lot of factors going into pain perception. If the damage is too great then what helped me may be too subtle. Over the past decade I had sustained periods in which it seemed like overall pain sensitivity increased, causing any body part with wear or tear to hurt more than seemed justified. At its worst I felt like a decrepit old man, though I'm five years younger than you. I feel very fortunate to have had this problem fade over the last two to three years. Unfortunately I can't be sure why. Some possibilities:</p><ul> <li data-xf-list-type="ul">palmitoylethanolamide—I did notice improvements within weeks of beginning this supplement</li> <li data-xf-list-type="ul">shifting hormone levels—I've been tweaking testosterone, estradiol and progesterone in this period. There is interplay between hormones and pain perception</li> <li data-xf-list-type="ul">peptides—speculative, and not the ones generally associated with healing. Oxytocin is a candidate, having some <a href="https://pubmed.ncbi.nlm.nih.gov/23887343/" target="_blank">research</a> behind it. GHK-Cu is also in the mix</li> <li data-xf-list-type="ul">fixing trashed hip—The theory behind it is stated <a href="https://www.medicalnewstoday.com/articles/high-pain-tolerance#causes" target="_blank">here</a>: "Chronic illnesses that cause pain may also lead to a type of hypersensitivity. People with chronic pain may become very sensitive to that type of pain, effectively reducing their pain tolerance." If you have one particularly bad area then it may increase your sensitivity in all areas. For me it can only be part of the story, as I was improving some even before surgery last year.</li> </ul></blockquote><p></p>
[QUOTE="Cataceous, post: 249644, member: 38109"] That's probably the data I was thinking of, with the range for Vermeulen free testosterone being 7-23 ng/dL, and the average about 14. My cautionary words are intended more for the broader audience, and we are on the same page with respect to low-and-slow on the TRT dosing. You have a lot of experience and know your own body much better than most. I don't presume to know what's best for you. I also don't in general object to guys experimenting with upper-normal levels if they have thoroughly evaluated normal and ideally lower-normal levels first. I'm wondering how often such cases receive a thorough investigation. And how common are they? What are the "T" symptoms, and how can we be sure they are exclusive to testosterone? A more prosaic problem than excessive CAG repeats or hyper-metabolizing would be an imbalance of androgenic and estrogenic activity. In this case there's a hypothesis linked to the TOT crowd, which is that the ratio of androgenic to estrogenic activity can be increased by pushing testosterone above what's physiological. The aromatase enzyme starts to saturate, reducing the incremental increases in estradiol. Then you get into the argument over whether high-doses of testosterone are better than micro-doses of an aromatase inhibitor. I don't want to give any false hope, because there are a lot of factors going into pain perception. If the damage is too great then what helped me may be too subtle. Over the past decade I had sustained periods in which it seemed like overall pain sensitivity increased, causing any body part with wear or tear to hurt more than seemed justified. At its worst I felt like a decrepit old man, though I'm five years younger than you. I feel very fortunate to have had this problem fade over the last two to three years. Unfortunately I can't be sure why. Some possibilities: [LIST] [*]palmitoylethanolamide—I did notice improvements within weeks of beginning this supplement [*]shifting hormone levels—I've been tweaking testosterone, estradiol and progesterone in this period. There is interplay between hormones and pain perception [*]peptides—speculative, and not the ones generally associated with healing. Oxytocin is a candidate, having some [URL='https://pubmed.ncbi.nlm.nih.gov/23887343/']research[/URL] behind it. GHK-Cu is also in the mix [*]fixing trashed hip—The theory behind it is stated [URL='https://www.medicalnewstoday.com/articles/high-pain-tolerance#causes']here[/URL]: "Chronic illnesses that cause pain may also lead to a type of hypersensitivity. People with chronic pain may become very sensitive to that type of pain, effectively reducing their pain tolerance." If you have one particularly bad area then it may increase your sensitivity in all areas. For me it can only be part of the story, as I was improving some even before surgery last year. [/LIST] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
“High-Normal T”
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