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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
“High-Normal T”
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<blockquote data-quote="Cataceous" data-source="post: 249549" data-attributes="member: 38109"><p>The burden of proof must be on those who would state it's safe to take triple the average youthful production. Not all risks are known and even the known risks are not so well quantified. Kudos to [USER=38590]@readalot[/USER] for his detailed explorations of this subject. The U-shaped mortality curve associated with testosterone levels should at least give pause to anyone contemplating long-term use of such high doses. If it takes giant doses of testosterone to resolve symptoms then shouldn't the focus be on why? It's not clear to me if even a relatively high CAG repeat length in the AR gene would need to be offset by such high levels. The natural increase in total testosterone from higher CAG repeat length isn't so pronounced. "The highest (n > 23) vs lowest quartile of CAG repeats (n < 20) associated with a 1.1 nmol/L [32 ng/dL] higher baseline testosterone level (F = 1.94, <em>P</em> = 0.02)."[<a href="https://journals.lww.com/cardiovascularendocrinology/Fulltext/2021/03000/Androgen_receptor_reduced_sensitivity_is.6.aspx" target="_blank">R</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 249549, member: 38109"] The burden of proof must be on those who would state it's safe to take triple the average youthful production. Not all risks are known and even the known risks are not so well quantified. Kudos to [USER=38590]@readalot[/USER] for his detailed explorations of this subject. The U-shaped mortality curve associated with testosterone levels should at least give pause to anyone contemplating long-term use of such high doses. If it takes giant doses of testosterone to resolve symptoms then shouldn't the focus be on why? It's not clear to me if even a relatively high CAG repeat length in the AR gene would need to be offset by such high levels. The natural increase in total testosterone from higher CAG repeat length isn't so pronounced. "The highest (n > 23) vs lowest quartile of CAG repeats (n < 20) associated with a 1.1 nmol/L [32 ng/dL] higher baseline testosterone level (F = 1.94, [I]P[/I] = 0.02)."[[URL='https://journals.lww.com/cardiovascularendocrinology/Fulltext/2021/03000/Androgen_receptor_reduced_sensitivity_is.6.aspx']R[/URL]] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
“High-Normal T”
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