Traverse

* TRT does not increase MACE risk in men with confirmed organic hypogonadism when titrated to physiological levels. Non-MACE signals warrant vigilance rather than contraindication. Metabolic optimisation should precede TRT in functional hypogonadism. Individualised monitoring and careful patient...

* Miner emphasized that TRAVERSE has reshaped the safety narrative around testosterone replacement therapy (TRT), easing concerns about cardiovascular and prostate risks. Many men with hypogonadism—who often suffer from fatigue, mood changes, and depression—are now more open to discussing TRT as...

* Although these epidemiologic data do not prove a causal relationship, they remind us that sex steroid hormones have complex actions and interactions in human health. https://www.acpjournals.org/doi/10.7326/M24-0875 Bradley D. Anawalt, MD University of Washington School of Medicine...

* Third, over 10% of men in the trial reported major depressive disorder or had severe depressive symptoms. TRT did not improve depressive symptoms in these men with major depressive disorder. Thus, TRT does not represent an effective treatment option for most men with clinical depressive...

In this episode, Dr. Brandon and Dr. Morgentaler talk about the long-standing belief that testosterone therapy increases the risk of prostate cancer, a fear that has influenced medical guidelines and practice for decades. 2:23 - Charles Huggins and Prostate Cancer Theory: Dr. Morgentaler...

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The relationship between testosterone replacement therapy (TRT) and cardiovascular(CV) disease (CVD) risk in older, hypogonadal men has been debated for years. Observational studies have variably linked low endogenous testosterone levels with adverse cardio metabolic effects and increased CVD...

ABSTRACT Men with hypogonadism have reduced risk of prostate cancer mortality; whether testosterone treatment increases the risk of prostate safety events in men with hypogonadism remains controversial. Several studies including four larger randomized trials — the Testosterone Trials...

Nelson's house is where it's at!

ABSTRACT Background The Cardiovascular safety of testosterone replacement therapy (TRT) among men with hypogonadism is not well established to date. Hence, we sought to evaluate the cardiovascular disease (CVD) outcomes among patients receiving testosterone therapy by using all recently...

Although the sole unequivocal indication for testosterone treatment is replacement therapy for male hypogonadism, off-label testosterone prescribing for aging men without pathologic hypogonadism rose dramatically (100-fold) over recent decades including 10-fold increases in the USA and 40-fold...

In this short video, I discuss the landmark results of the prostate study from TRAVERSE, which should forever alter clinical practice and medical concepts. I’ve been working on the testosterone and prostate cancer question for 30+ years, and finally, there is a large, randomized controlled trial...

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2814401 Abstract Importance The effect of testosterone replacement therapy (TRT) in men with hypogonadism on the risk of progression from prediabetes to diabetes or of inducing glycemic remission in those with diabetes is...

https://www.medscape.com/viewarticle/999636?form=fpf Rachel S. Rubin, MD: I am Dr Rachel Rubin, urologist and sexual medicine specialist in the Washington, DC, area. I am so blessed to have with me one of my favorite sexual medicine doctors on earth, Dr Mo Khera, professor of urology at...

https://www.nejm.org/doi/pdf/10.1056/NEJMoa2308836 Background Testosterone treatment in men with hypogonadism improves bone density and quality, but trials with a sufficiently large sample and a sufficiently long duration to determine the effect of testosterone on the incidence of fractures...

"So far, we have only 2 published, which is the cardiovascular results, which showed no increase in cardiovascular events, and the sexual function results, showing improvements in libido, but not erectile function, in up to 2 years," says Mohit Khera, MD, MBA, MPH...

Abstract IMPORTANCE Testosterone deficiency causes mild anemia. Whether testosterone replacement therapy (TRT) can correct anemia or prevent the development of anemia in men with hypogonadism remains incompletely understood. OBJECTIVE To assess the efficacy of TRT in correcting anemia in...

Abstract Purpose of Review The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. Recent Findings A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many...

https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad555/7280102 Over the past decade, concerns about the adverse effects of testosterone have paralleled the escalating rates of testosterone prescriptions (1). The principal safety concerns for testosterone therapy have...

https://www.nejm.org/doi/10.1056/NEJMc2309389?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://www.nejm.org/doi/10.1056/NEJMc2309389?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed...

Bradley D Anawalt University of Washington School of Medicine, Seattle, WA 98195, USA. For decades, there has been controversy about whether testosterone therapy has deleterious effects on the risk of major cardiovascular events in older men. As the number of prescriptions for testosterone...

50:04-52:16 (non-fatal arrhythmias, atrial fibrillation, acute kidney injury) Josh and Adam discuss the new NEJM study on the use of Testosterone in men at high risk for cardiovascular events.

“Because this was the largest trial ever of testosterone replacement therapy, although the primary point of the trial was cardiovascular safety, we embedded within the trial several efficacy and other sub-studies,” says A. Michael Lincoff, MD...

https://www.drmohitkhera.com/traverse-trial/ *Comprehensive Design and Execution of the TRAVERSE Trial *Discerning the Implications of the TRAVERSE Trial *TRAVERSE Patient Selection and Clinical Application Future Perspectives and Conclusion The TRAVERSE trial is a beacon for future...