#stimulants

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  1. B

    TRT lack of energy, motivation and loss of sensitivity to stimulants due to E2 ?

    I know High E2 can cause depression, low motivation, low energy, etc.... especially if one is low SHBG then you are even more sensitive to E2 issues... I was wondering could High E2 cause someone to also be less affected by stimulants, etc.... Possibly could E2 affect dopamine levels as well?
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