role of 5-ar in physiology and metabolic disease

ABSTRACT The 5-reductases (5α-reductase types 1, 2 and 3 [5αR1− 3], 5β-reductase [5βR]) are steroid hormone metabolizing enzymes that hold fundamental roles in human physiology and pathology. They possess broad substrate specificity converting many steroid hormones to their 5α- and 5β-reduced...