#no motivation

Fatty liver and Trt

I was diagnosed with Fatty Liver back in 2017, however my testosterone was dropping alongside of it ! I spoke to my pcp about the issues I was seeing and having and asked if I could be placed on TRT. His short but quick answer was absolutely not! He gave me multiple reasons with many other...
- Orthonurse
- Thread
- Jul 24, 2025
- #lowt #no motivation depressession man boobs men muscle loss sex drive weight loss
- Replies: 4
- Forum: Testosterone Basics & Questions
B
TRT lack of energy, motivation and loss of sensitivity to stimulants due to E2 ?

I know High E2 can cause depression, low motivation, low energy, etc.... especially if one is low SHBG then you are even more sensitive to E2 issues... I was wondering could High E2 cause someone to also be less affected by stimulants, etc.... Possibly could E2 affect dopamine levels as well?
- BillyJ03z
- Thread
- Apr 1, 2019
- #e2 #lack of energy #no motivation #stimulants high e2
- Replies: 6
- Forum: Testosterone Basics & Questions

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038