kisspeptin; reproduction; hssd; testostreone

Intranasal kisspeptin-54 administration rapidly stimulates gonadotropin release in humans

* We demonstrate the clinical potential for intranasal kisspeptin delivery as the first non-invasive method to robustly and safely stimulate gonadotropins with kisspeptin and potentially transform the management of reproductive disorders. * In summary, we provide the first human evidence...
- madman
- Thread
- Apr 24, 2025
- kisspeptin; reproduction; hssd; testostreone
- Replies: 1
- Forum: Testosterone and Men's Health Articles
Intranasal kisspeptin: a novel, effective, and non-invasive approach to stimulate reproductive hormones

https://www.endocrine-abstracts.org/ea/0094/ea0094oc4.4 Background Kisspeptin is a potent regulator of GnRH neurons with the potential to treat reproductive and psychosexual disorders. However, administration is limited to the subcutaneous or intravenous routes. These invasive routes limit...
- madman
- Thread
- Dec 29, 2023
- kisspeptin; reproduction; hssd; testostreone
- Replies: 3
- Forum: When TRT Is Not Enough (ED, Libido, & More)
Novel therapeutic avenues for kisspeptin

Novel therapeutic avenues for kisspeptin (2022) Jovanna Tsoutsoukia, Ali Abbarab, and Waljit Dhillo Abstract Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In...
- madman
- Thread
- Dec 9, 2022
- kisspeptin; reproduction; hssd; testostreone
- Replies: 10
- Forum: HRT in Women

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038