hypogonadsim; polymorphism ar/cag repeat length

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  1. madman

    "Genetic Insights into Androgen Receptor Sensitivity: Optimizing Testosterone Therapy for Male Hypogonadism"

    https://www.endocrine-abstracts.org/ea/0109/ea0109oc3.5 The Androgen receptor (AR) CAG repeat polymorphism in exon 1 within human populations encodes for a polyglutamine stretch which varies between 9 to 35 repeats. The greater the number of CAG repeats the less sensitive the receptor in...
  2. madman

    Effect of Androgen Receptor Polymorphism on Hypogonadism Severity

    *Average number of CAG repeats found was 23 ± 3.1, which is within the normal range as described by current literature * Half of the patients (n=8) had [EF] subscores <14, indicating erectile dysfunction. However, Wilcoxon testing reveals that this difference is not significantly less than the...
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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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