fertility; t/e ratio; sperm; estradiol

Managing the Testosterone-to-Estradiol Ratio in Men on TRT

Managing the Testosterone-to-Estradiol Ratio in Men on TRT Introduction Testosterone replacement therapy (TRT) in hypogonadal men often leads to an increase in estradiol (E2) levels due to the aromatization of testosterone. This alters the testosterone-to-estradiol (T:E) ratio, a metric...
- Nelson Vergel
- Thread
- May 29, 2025
- fertility; t/e ratio; sperm; estradiol high estradiol t/e ratio t/e2 ratio
- Replies: 8
- Forum: Testosterone Side Effect Management
T/E ratios in Fertile and Subfertile Men

* This is the largest study to date characterizing testosterone to estradiol ratios in men presenting for fertility evaluation. We validated the 10/1 ratio that was previously established as the 20th percentile for fertile men. OBJECTIVE To validate the established normal testosterone to...
- madman
- Thread
- Jan 3, 2025
- fertility; t/e ratio; sperm; estradiol
- Replies: 4
- Forum: Testosterone and Men's Health Articles

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038