depression in men

  1. Seagal

    The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men

    The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789012/ Best review on this topic I have seen so far. Might be also very interesting for non-depressed ageing and young men. "In...
  2. Seagal

    Bioavailable testosterone is associated with symptoms of depression in adult men

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557700/ Results Mean testosterone, sex hormone-binding globulin, and luteinizing hormone levels were significantly higher in the depressive symptom group than in the non-depressed group. The mean calculated free serum testosterone level and free...
  3. T

    TRT alleviating depression?

    Has anyone experienced relief or reversal of depression, irrespective of dose or type of TRT? Yes, I have untreatable bipolar. For years, now, my primary symptom is depression and anhedonia. Those two are linked but not necessarily the flip side of one or the other, at least as I seem to...
  4. C

    When Depression Strikes

    In July of 2018 I was six months past my 60th birthday and enjoying a Canadian summer, looking forward to a number of trips my wife and I had planned. By the end of August I had lost three friends to death and saw my own health being threatened. By September, always a wonderful month in Toronto...
  5. Nelson Vergel

    Helping a man at risk of suicide

    It has been difficult for me to process the fact that Dr. Crisler took his own life. I struggled to share this but if we can prevent at least one of you from taking your own life, then this discussion is worth it. My sister committed suicide two years ago and I have not yet come to terms with...
TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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