d-chiro-inositol/aromatase downmodulator

D-chiro-inositol, an aromatase downmodulator, increases androgens and reduces estrogens in male volunteers

Abstract Background: Androgen deficiency affects men in adulthood, causing several harmful effects at the reproductive and behavioral levels. Since aromatase is an enzyme that catalyzes the conversion of androgens to estrogens, and it is responsible for an adequate balance of both sex hormones...
- madman
- Thread
- Jun 3, 2021
- d-chiro-inositol/aromatase downmodulator
- Replies: 13
- Forum: Testosterone Side Effect Management

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038