Cardiovascular Safety

Sex differences in the risk of cardiovascular disease have been attributed to differences in sex hormone concentrations between men and women. In premenopausal women, endogenous estrogens are thought to confer a protective effect on the vasculature in delaying the onset of cardiovascular disease...

Adverse cardiovascular events and mortality in men during testosterone treatment: an individual patient and aggregate data meta-analysis (2022) Jemma Hudson, Moira Cruickshank, Richard Quinton, Lorna Aucott, Magaly Aceves-Martins, Katie Gillies, Shalender Bhasin, Peter J Snyder, Susan S...

ABSTRACT Background: Testosterone exerts some effects on the cardiovascular system that could be considered beneficial; some other effects may potentially increase the risk of cardiovascular (CV) events. Neither the long-term efficacy nor safety of testosterone treatment has been studied in an...