Biology

Complex allosteric mechanism! * The transport of sex steroid hormones in the plasma is largely mediated by sex-hormone binding globulin (SHBG). SHBG is a functional homodimer, meaning it can bind two sex hormones with similar affinities. This binding occurs through a complex allosteric...

Presented by Dr. Steve Winters, Emeritus Professor, Division of Endocrinology and Metabolism Endocrinology Grand Rounds Summary Introduction Sex hormone-binding globulin (SHBG) represents one of the most clinically significant biomarkers in endocrinology, with implications extending far beyond...