allosteric perturbations

  1. Nelson Vergel

    How to Increase Allopregnanolone, The Happiness Neurosteroid.

    DEEP DIVE: Strategies to Increase Allopregnanolone A Comprehensive Review for Mental Health Support 1. What is Allopregnanolone? Allopregnanolone (ALLO) is a neurosteroid synthesized from progesterone that acts as a potent positive allosteric modulator of GABA-A receptors. [1,2] Its potency at...
  2. madman

    Integrated structural analysis of SHBG reveals allosteric modulation by distant mutations

    Most recent paper, Bhasin and Jasuja! * Understanding the structural arrangement of LG domain, its interaction with rest part of the protein as well as internal dynamics provides valuable insights into the molecular mechanisms governing its function as a carrier protein for sex hormones...

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