1. #1

    Biological Changes not Seen following Testosterone Therapy

    A small randomized controlled trial of testosterone therapy saw beneficial changes after six months, but failed to observe expected changes in biological markers:



    Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels. In this exploratory small-scale study, the beneficial effects of six-month TRT on total testosterone, LBM, and percent body fat were not followed by significant changes in fractions of mitochondria, glycogen, or lipid in skeletal muscle of aging men with lowered testosterone levels. Six-month ST or combined three-month ST+TRT did not change intramyocellular mitochondria, glycogen, and LD fractions compared to placebo. However, further studies with a larger sample size are needed.

  2. # ADS
    Purchase From Our Affiliates
    Join Date
    Always
    Posts
    51
    Help Excelmale

    Defy
     

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Testosterone Therapy Reduces Risk of Rehospitalization in Older Men With Low Testosterone.
    By Nelson Vergel in forum Testosterone- Miscellaneous Studies
    Replies: 1
    Last Post: 05-31-2017, 04:07 PM
  2. DHT and estradiol correlate to slowdown of biological aging
    By Nelson Vergel in forum Prevent & Reverse Side Effects (HCG, Anastrozole, etc)
    Replies: 0
    Last Post: 05-11-2016, 04:01 PM
  3. Do I need testosterone therapy?
    By kornmasaok in forum Blood Test Discussion
    Replies: 6
    Last Post: 11-04-2015, 03:02 AM
  4. Replies: 1
    Last Post: 09-05-2015, 08:20 AM
  5. Defending plasma T3 is a biological priority
    By Nelson Vergel in forum Thyroid, DHEA, Cortisol, Prolactin, Pregnenolone and More
    Replies: 0
    Last Post: 10-19-2014, 09:39 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •