1. #1

    Trough serum testosterone predicts the development of polycythemia



    Objectives Testosterone formulations that have more steady-state pharmacokinetics, such as subcutaneously implanted testosterone pellets, may cause less erythrocytosis than i.m. injections of shorter acting androgen esters. We, therefore, sought to define the prevalence, predictors, and proximate basis (role of erythropoietin) for polycythemia (hematocrit >0.50) in hypogonadal men receiving testosterone implants long term.
    Design A cross-sectional study was conducted in an academic andrology center with a longitudinal subgroup analysis.
    Patients A total of 158 hypogonadal men aged 14–84 years (mean age 46.7 years) treated on average for 8 years (range 0–21 years).
    Measurements Trough blood testosterone and hematocrit. Serial serum erythropoietin concentrations were measured in 16 volunteers.
    Results Positive univariate associations between polycythemia (hematocrit >0.50) and log(testosterone) (odds ratio (OR) 24.7, 95% confidence interval (CI): 4.3, 141.2, P<0.01) and age (OR 1.1, 95% CI: 1.0, 1.1, P=0.03) and a borderline relationship with current smoking (OR 4.2, 95% CI: 0.9, 20.0, P=0.08) were unveiled. A sensitivity analysis using alternate definitions of polycythemia was performed to capture all potential covariants. Multivariate regression analysis incorporating all potential covariants disclosed the independent OR of developing polycythemia (after adjusting for smoking and age) for log(testosterone) to be 15.0 (95% CI: 2.5, 90.8). Duration of testosterone therapy did not alter the risk of polycythemia. A direct relationship between testosterone and erythropoietin was observed (P=0.05).
    Conclusions Higher trough serum testosterone concentrations but not duration of treatment predict the development of polycythemia in men receiving long-acting depot testosterone treatment.”

    A lot of people on TRT report that HCT increased after doing more frequent injections. With less frequent injections trough is lower. I guess because the body has some time with lower testosterone lower (well within physiological levels) the effect on hematocrit is lower.

  2. # ADS
    Purchase From Our Affiliates
    Join Date
    Help Excelmale


Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Testosterone Decline Predicts Early Death
    By Jinzang in forum Testosterone- Miscellaneous Studies
    Replies: 0
    Last Post: 10-27-2017, 11:21 AM
  2. Severe Polycythemia for Testosterone. What now?
    By firemedicpn63@gmail.com in forum Testosterone Basics & Questions
    Replies: 18
    Last Post: 06-20-2016, 07:20 AM
  3. Severe Polycythemia for Testosterone. What now?
    By firemedicpn63@gmail.com in forum How to Use This Site
    Replies: 10
    Last Post: 06-18-2016, 01:45 PM
  4. Testosterone supplementation associated with development of DVT-PE-osteonecrosis
    By Charles Glueck in forum Prevent & Reverse Side Effects (HCG, Anastrozole, etc)
    Replies: 3
    Last Post: 12-15-2015, 08:44 AM
  5. Replies: 1
    Last Post: 12-14-2015, 07:46 AM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts