1. #1
    Super Moderator Nelson Vergel's Avatar
    Join Date
    Sep 2013
    Houston, Texas, United States

    Low Estradiol Increases Hot Flashes and Sweating in Men with Low Testosterone

    Note: VMS are episodes of profuse heat accompanied by sweating and flushing, experienced predominantly around the head, neck, chest, and upper back.

    Effects of Testosterone and Estradiol Deficiency on Vasomotor Symptoms in Hypogonadal Men.
    Randomized controlled trial

    Taylor AP, et al. J Clin Endocrinol Metab. 2016.

    CONTEXT: The hormonal basis of vasomotor symptoms (VMS) in hypogonadal men is incompletely understood.

    OBJECTIVE: To determine the contributions of testosterone and estradiol deficiency to VMS in hypogonadal men.

    DESIGN: Two randomized trials were conducted sequentially between September 2004 and April 2011. Controls were recruited separately.

    SETTING: A single-site academic medical center.

    PARTICIPANTS: Healthy men ages 20-50, with normal serum testosterone levels.

    INTERVENTION: Cohort 1 (n = 198, 81% completion) received goserelin acetate every 4 weeks to suppress gonadal steroids and were randomized to placebo or 1.25, 2.5, 5, or 10 g of testosterone gel daily for 16 weeks. Cohort 2 (n = 202, 78% completion) received the same regimen as cohort 1 plus anastrozole to block aromatization of testosterone. Controls (n = 37, 89% completion) received placebos for goserelin acetate and testosterone.

    MAIN OUTCOME MEASURES: Incidence of visits with VMS. This was a preplanned secondary analysis.

    RESULTS: VMS were reported at 26% of visits in cohort 1, and 35% of visits in cohort 2 (P = .02), demonstrating an effect of estradiol deficiency. When adjacent estradiol level groups in cohort 1 were compared, the largest difference in VMS incidence was observed between the 5-9.9 and 10-14.9 pg/mL groups (38% vs 16%, P < .001). In cohort 2, the 10-g testosterone group differed significantly from placebo (16% vs 43%, P = .048) after adjustment for small differences in estradiol levels, indicating that high testosterone levels may suppress VMS.

    CONCLUSIONS: Estradiol deficiency is the key mediator of VMS in hypogonadal men. At high levels, testosterone may have a suppressive effect.

    Author of Testosterone: A Man's Guide & Built to Survive

    Please no private messages. I answer questions on the forum for all to benefit.

  2. # ADS
    Purchase From Our Affiliates
    Join Date
    Houston, TX
    Help Excelmale


Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Hot Flashes and Low E2
    By pm3405 in forum Prevent & Reverse Side Effects (HCG, Anastrozole, etc)
    Replies: 11
    Last Post: 03-13-2017, 02:48 PM
  2. Hot Flashes when E2 is low??
    By Gianluca Bonetti in forum Prevent & Reverse Side Effects (HCG, Anastrozole, etc)
    Replies: 7
    Last Post: 09-14-2016, 07:06 PM
  3. Low Estradiol May Cause Hot Flashes and Night Sweats in Men
    By Nelson Vergel in forum Testosterone- Miscellaneous Studies
    Replies: 4
    Last Post: 06-26-2016, 12:41 PM
  4. Hot flashes
    By fmalianos in forum Testosterone Basics & Questions
    Replies: 3
    Last Post: 08-04-2015, 05:21 PM
  5. Men with Low Testosterone and Higher Estradiol Are More Prone to Heart Attacks
    By Nelson Vergel in forum Testosterone- Miscellaneous Studies
    Replies: 0
    Last Post: 09-15-2014, 10:54 AM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts