1. #1
    Super Moderator Nelson Vergel's Avatar
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    Sep 2013
    Houston, Texas, United States

    Aspirin inhibits HCG induced increase in testosterone and other hormones

    Eicosanoids play an important role in the regulation of the hypothalamic-pituitary axis; less clear is their role in testicular steroidogenesis. To evaluate the involvement of cyclooxygenase metabolites, such as prostaglandins, in the regulation of human testicular steroidogenesis, we examined the effects of a prostaglandin-blocker, aspirin, on plasma testosterone, pregnenolone, progesterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17β-estradiol response to human chorionic gonadotropin (hCG) in normal male volunteers in a placebo-controlled, single-blinded study. To test the efficacy of aspirin, seminal prostaglandin E2 levels were also determined. hCG stimulation increased peripheral levels of testosterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17β-estradiol, without affecting circulating pregnenolone and progesterone values. Aspirin significantly lowered seminal prostaglandin E2 levels, whereas it did not modify steroid concentrations not exposed to exogenous hCG. Moreover, the drug significantly reduced the response of testosterone, 17OH-progesterone, androstenedione, and dehydroepiandrosterone to hCG, as assessed by the mean integrated area under the curve, whereas it did not influence 17β-estradiol response. In conclusion, aspirin treatment inhibits androgen response to chorionic gonadotropin stimulation in normal humans. The action of aspirin is probably mediated via an effective arachidonate cyclooxygenase block.

    Full paper:
    Aspirin inhibits androgen response to chorionic gonadotropin in humans.

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  3. #2
    Junior Member
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    Jun 2017
    I remember there was a study about NSAIDS a few years ago that said it was negative on muscle gains too

  4. #3
    Junior Member KennyT's Avatar
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    Oct 2016
    Tampa, Florida
    so by taking aspirin at 85 mg once a day for my heart i'm killing my testosterone ?
    no wonder its low.

  5. #4
    Junior Member
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    Jun 2017
    well you should be doing other methods to reduce your heart attack risk then relying on aspirin

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