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I do take 1200 Mg of NAC a few times a week. What is a goof NAC protocol? What is the MTHFR mutation and how does one deal with it? I am actually starting to get some energy back, which is good. Went to gym yesterday and today. Still not much of a libido, but did wake up with morning wood.

I only ever got to the high 380s for total T on clomid. But even when my T was in the 700s and 800s, I never felt consistently good on TRT. I am being patient with my psychiatric treatment and then I'll wrestle with the hormone stuff if I am still symptomatic. I think I will reorder the...

Hey Fellas, Just wanted to give you an update: I just started some SSRI treatment (Lexapro 10 mg daily) and kolonopin as needed for my mental health issues. (had tried Wellbutrin and Zoloft and xanax before my TRT journey) So far, so good, but I feel pretty lethargic and my libido is pretty...

Thanks for the encouragement...so Dr. Saya got back to me (so incredibly attentive and caring!). I can stop the Clomis cold turkey b/c of the long half life. I will keep you updated about how the mental health side goes. Dr. Saya did also say that if all else fails Defy could provoide proper...

So I think I might try to titrate down (and off) the Clomid with the supervision of Dr. Saya and Defy, of course. When I bumped up to 25 mg/day about two weeks ago, after a few days I felt a bit better, but now I am feeling very low and depressed with ZERO libido. My usual problem mentally was...

Nelson, are you still on Zoloft? If not, how long did you use it? If so, how long did you start to feel a difference. I have an appt finally with a really good psychiatrist this Friday. I had tried Zoloft over a year ago (before TRT) and it didn;t really works..sides were hard for me. Then did...

Just a little update on my journey. Have been on 25Mg clomid every day for two weeks. Up from 12.5 Mg every day for about 6 weeks). To be honest, the first half week on increased dose was rough, but then I started to feel really good again. My libido was up erections were good, energy was...

As always thanks for lending your expertise to the board and to me as a patient. I totally get my options if teh Clomid does not work out for me. I guess my wife and I are leery of TRT b/c I really wasn't doing well on it. The question now is IF the Clomid doesn't work, what option do we...

Just a quick question: Can Clomid cause depression even without elevated E2 levels? Have a appt with psych next week b/c my wife and I feel an SSRI or another med (again!) might help with this. Normally I suffer from anxiety, but not really depression. The anxiety has actually not been bad...

Excellent. Thanks again for all your help. My wife and I are incredibly impressed with your level of care, sympathy, and attention. Thank you!

Thanks, Doc. That kind of makes sense to me. I'll start doing 25mg/day until our next follow up consult/bloods in 2.5 months. My wife and I have also decided I really need to give an SSRI a try again to see if it could alleviate some of the depression, etc. Thanks for you time, expertise, and...

Got blood work back just now. Really makes no sense to me. This is now after 2 months daily clomid 12.5 day and DIM and Calcium D. Glucarate Blood from Friday May 6 2015 Blood from March 28 2015 (about 2 months into clomid) (1 month into clomid) Total Test. 386 (range...

Thanks, Doc. Will do...I'm very curious to see what the numbers will show.

Thanks for the support. I just heard from my uro and the blood work won't be back for another day or so, so I'll have to wait. I was going to wait to have bloodwork in hand to send to Defy, buy I think I'll alert them now anyway to keep them in the loop.

He did pull the sensitive E2 along with some other things I asked for (I updated previous post.) I'll share when I get them. Do guys use arimidex while on Clomid if they had been feeling well and E2 wrecks it? Hopefully I can make it through the three months Dr. Saya and I agreed to do with the...

Oh man, what a crazy few days. As you know I had been doing very well on the Clomid for the past month or two. Dr. Saya and I had our consult and decided with the positive subjective symptom relief to stay the course and get new bloods in 3 months. Well, last week I started to lose some vigor...

Ultimate goal is to slowly titrate down and get off. From my discussion with Dr. Saya though, there is a place for long term low dose Clomid if the bloodwork and symptoms don't cooperate with the removal of Clomid altogether. So hopefully, I'd be slowly weaned off and have no need for the...

So had my consult with Dr. Saya today after about 5 weeks on the Clomid (12.5 mg) day with some DIM and Calcium d-Glucarate to manage E2. I am feeling really good right now - probably the best I have in 2 years on or off TRT. The plan we've decided upon is to stay the course with low dose...

Just wanted to provide an update. I'm actually feeling really good. Still on 12.5 mg per day of the Clomid, a multi-vitamin, and 4000 iu of vitamin D daily. Dropped the DIM. I also take a compounded 25mg preg/15 mg DHEA before bed each night. Mood, libido, erection, mental focus have been very...

I had tried Zoloft and then Wellbutrin before turning to TRT. I am working with a good therpaist weekly now. Believe me, I have tried anything I could to alleviate my negative symptoms.

I've felt as bad or worse on traditional TRT as well...I'm willing to be patient and wait. For about half of the time on this restart I felt very good. Now, not so much, but I'm willing to wait and see. Traditional TRT, even when I seemed to have good numbers never got me feeling good...

Just got blood results from Monday. I haven't had any cypionate since mid February, followed by 2 weeks of HcG and then three weeks of the Clomid. I had been on the Clomid 12.5 mg + 120 mg DIM indoplex per day for about 20 days. I have also been taking a capsule of 15mg DHEA + 25mg pregnenolone...

So I got blood work done this morning at primary care doc (Total T, Free T, SHBG, Estradiol[sensitive], LH, and FSH) as suggested by Dr. Saya. I look forward to scheduling a follow up consult with Dr. Saya to discuss them when I get the results back. I'll be sure to keep the board updated about...

I felt good on LD clomid for a bit (but I'm only less than a month in). My ultimate goal is to be off TRT, deal with my natural levels and mental health issues. There were times on TRT that I felt okay or even good, but a lot of the time I felt pretty bad. The lifetime commitment just doesn't...

Dr. Saya, I can't thank you enough for being so available to those of us in your care. For the first time in my TRT journey, I feel that I am in competent hands. Thank you! Thank you! Thank you! Happy Easter to you and yours. Best, Xerxes

Happy Easter everyone. Just an update that last night and now this morning, I am very weepy for some reason. Definitely will be reaching out to Defy tomorrow to see what they think and maybe get some blood work done. I am so tired of chasing answers and ways to feel better. It's so frustrating...

Yeah, I'm not making any protocol changes. I'll check in with Defy after the holiday. It's not any crisis situation. And I can't say it's my traditional anxiety really. Just emotionally flat and no libido. Just just be the reality of what a restart is like. I just felt pretty good from day 9 to...

I'm 35. Have two beautiful daughters already with no desire for more. Trying a clomid restart because I had no stability on TRT (for 7-8 months). Under the supervision of Dr. Saya over at Defy we decided I was young enough to give the restart a shot. I am still hopeful, but man the last few days...

Another update...over the last few days it seems like my reaction to the clomid is either taking a negative turn or I need to just be more patient, which is a bit frustrating because I had felt so good just a week ago. Basically my libido has dropped off the face of the earth and my anxiety is...

Quite the opposite! I am happy to hear of other guys' experiences. If clomid could be helpful to some men, I think it would be good to have a thread that guys searching online can find and learn from. Good luck with your treatment!

I think the plan to do blood work in early April and then based on that titrate down with the goal of eventually stopping the clomid. I think whatever Dr. Saya and I decide it will be slow and steady. And if a low dose of clomid is the long term answer (I've read that Dr. Saya and Dr. Crisler...