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For some men it seems that high estrogen or low dht to estrogen ratio causes brain fog.

Hi @Nelson Vergel, is it possible to link the references to the statements/paragraphs of the text?

You could try a higher weekly dose increasing gradually from 80 to 120 mg

What did you expect to feel?

I felt the T gel almost immediately while having had total T of 150. Wait for the second appointment when he has your lab values. They should have tested free testosterone. Probably they tested shbg and albumin from which one can calculate an estimate of free testosterone. The full effects of...

SHBG in single digit is not good. Free T is high. You could try a lower weekly dose; 3x30mg per week. Edit: your free testosterone test is probably not correct. The calculated fT is around 13 thus not high. Prolactin seems elevated maybe from psych meds. Some CBC markers are out of range...

What is then the optimal TRT Dose for muscle growth for older adults? 125mg?

0.5mcgs e3d is more than 1mg per week. My advice on dosing: inject at least twice per week and increase dosis until you feel the food noise/appetite suppression.

Too bad. Since you are sort of lean, you should increase to at least maintenance calories and track your subcutaneous fat.

I think you need to add more calories and just do TRT plus Reta. Have you tried that?

We were talking about achieving a peak thus no stable proviron levels. Works like a modulator to obtain quasi circadian level variations. That's how it feels for me.

Also from Germany. Have the Testogel 1.62%. I need 37mg proviron to feel an effect. Gonna try the gel again.

What is the T gel you are using? I tried androgel on scrotum but I don't feel it like you do. How did you dose proviron?

Your calculated free testosterone is 330pg/ml. Far above range instead of low. Maybe your high T levels are negatively impacting your sleep

Melatonin for better sleep?

E2 follows T. Adjustment of aromatization might take a while. You could skip a week of injections, this might give your body more time for clearance of E2. I would then continue with 60-70mg split into two sc injections per week. If you feel better with eod or ed, then do that.

It's possible that your body slowly adjusts the aromatization of T to E. Now your fT as well as your E is high. That's normal. Also sometimes the E lab test overestimates. My suggestion: reduce the dose and bring your fT in range (around 20pg, maybe you can get there with 60-70mg T per week)...

After how many months on TRT was the July test?

I think you should also focus on your free levels. You listed free T being high. Don't know how to convert your dht to free dht but with low shgb is should move from low to at least middle. My theory on SC injections: different sites, different metabolism. If you injected into the belly region...

Testosterone undecanoate with the nebido protocol injecting 4ml deep IM at once has the POME risk warning. Versus small volumes (0.3ml) and shallow IM injection... With SC injection there is even less risk. That are parameters I would keep track off if wanted to study the risk of POME with TRT...

For an average of 500 normally less than 100mg per week is needed! You could also try testosterone undecanoate if you benefit from a stable T level.

I would say cortisol is related to stress (good and bad stress), wakes one up in the morning. A cold shower should give you cortisol release. Haven't used TP so far. With androgel applied in the morning, I experienced a significant mood change in the afternoon, similar to when I was T deficient...

This can also include higher sensitivity to psychological aspects. Pros and cons, mostly more difficult though. Back to T: for me the change of dropping T feels not good. I decided for weekly TU. The negatives you mentioned might also be related to cortisol spikes.

Alcohol, fructose, glp1 https://www.nature.com/articles/s42255-025-01402-x

Nothing mentioned about testosterone or dht?

Did you change your nutrition or meal portions? Do you supplement with carnitine?

I'm sort of a highly sensitive person. So, if someone is in the same boat, better start with 0.5mg.

1mg at once. Second day constipation.

I have underlying MDD and maybe that's why GHK-cu has that effect for me. Impact on neurotransmitter regulation and anti-inflammatory effect in the brain are possible explanations.

Your thread motivated me to look again for a source. Hope I got real Reta. I have started yesterday with 1mg.

Retatrutide has a halflife of 5 days. Do you notice it? Would twice weekly be better?