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Thanks Vince. I actually spent all of last year titrating dosages to combat sides without an AI, but by the time I had titrated down enough to combat the E2 sides I was getting no benefit from TRT. I enrolled with Defy to explore my options and have been extremely conservative with dosages and...

Appreciate the response and understood. I’ve been at this for over a decade at very low dose (42mg a week) but can’t say I ever felt great. 42mg/wk was the level that I stopped having estrogen side effects with no AI (I am true hypo, test was in the low 100s when I began treatment). The...

Hello! Long time lurker, first time poster. First and foremost - I wanted to thank all the TRT experts on this forum. I’ve benefited immensely from your knowledge and direction in this journey. Current Protocol: 6’ tall, 260 lbs (overweight) 40MG E3D (0.2 ML test e 200/ml) .075 Anastrole...