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Yeah, these are brutal symptoms. I ask if there are other symptoms (like joint symptoms, sexual symptoms, fatigue, infections, hairloss etc) because as of now I've talked to a dozen of AI crashers and I'm trying to find a pattern. As of now it's apparent reversible AI crash cases shouldn't be...

Any other symptoms besides that? Have you tried exogenous E2, on TRT or off it? Or what other things have you tried? Maybe HCG or anything more exotic? And what do your blood tests say?

I know someone that crashed with aromasin and for 2 years had low E2 symptoms. He fixed himself permanently with few tablets of oral E2. Quite crazy. Another dude fixed himself with many doses of high doses of E2 cypionate injections. However AI crash cases vary too much to figure out an...

This is an extremely complex situation you're in. Forums like these don't understand these conditions. I recommend checking out people that have experience with helping ppl with stuff like this, like joshua leisk's bornfree protocol and alex kikel. Have you had any tests done of any kind...

Btw, this is interesting about your cholesterol levels. Mine were too low for a while as well. Sex steroid levels are high but cholesterol very low. Might be related to thyroid function? Absorption difficulties might be present too. I'll try TUDCA.

Do you guys mind sharing your sources for MIF-1?

This is interesting. So after the surgery you lost erections AND libido? Do you perhaps remember what drugs/meds (if any) you were given prior to surgery?

Thanks. Yeah, estradiol does a lot of stuff. Once you understand how much stuff it's involved in and what it does you understand it's not wise to mess with it. I learned that a bit too late. But I will fix this sooner or later. I think PAIS isn't of one type. Just like PFS and PSSD aren't. PAIS...

(Me being one of those people, lol)

I believe this approach cannot work. This is how mainstream medicine works. Patching up symptoms, making you worse in the long run. It's avoiding treatment of underlying issues. Worse, this cannot work even short-term. A "cabergoline trial" is dangerous. If prolactin elevation is not caused by...

In fact, even before human trials it was already proven on rats that SSRIs cause typical sexual symptoms. Though, for ppl with severe PSSD, sexual symptoms are the least of their worries.

You said you havent taken accutane or finasteride. What about: SSRIs, benzos, antipsychotics? Or what about: saw palmetto, lions mane? Before 2012, have you been taking any medications (antibiotics) or supplements (overdosing on zinc?)? Used any psychedelics, or other drugs? Were you poisoned...

Yes, this is no wonder. Estrogen is crucial for libido. Your e2 levels might be okay but that doesnt tell us if there's proper estrogen signalling taking place. Also, there's balance between ERalpha and ERbeta that serum e2 levels tell us nothing about but is important still.

Bro, his issues have literally everything to do with AI use. That doesn't mean that we ought to focus on e2 levels now. Most people and docs have literally 0 knowledge about the involvement of estrogen in thyroid function (overall metabolism rate), endocannabinoid system, andregenic system...

Did you use AIs on TRT?

Okay, that's interesting. Do you use any supplements?

I would say that if viagra or cialis don't help then the issue is not high E2 in itself. Dropping E2 has a downstream effect on various processes but we would have to find out what exactly does it affect that might be relevant for erections. The dopamine agonist you're using might be playing a...

Have you ever tried supplementing with high-ish doses of alpha gpc? Without acetylcholine with which these nootropics interact it's possible to have erection problems.

PSSD is a way to describe a set of symptoms induced specifically by SSRIs. Many conditions have similar symptoms. Even some long covid cases have symptoms like that. You were predisposed by something so that you reacted this way to few pills of tamox. Don't worry too much, it's reversible. TRT...

There can be underlying issues for which contributing factors most doctors don't care to look for. Typical tests that doctors do can reveal some hints if a competent doctor can interpret them correctly. The fact that you felt like shit is an evidence enough that something was off. And low test...

You're young (saw your profile) so low test levels and feeling shitty would be likely due to some nutrient deficiency. Using TRT can be avoided by making some lifestyle changes, better diet, exercise etc., specific mineral/vitamin supplementation (I know, all sounds bullshit but it's true). It's...

True. NO synthase is iron based enzyme so iron is crucial. Also there needs to be balance between estrogen which increases copper metabolism which increases SODs which keeps NO going via eradicating free radicals that are made when NO is synthesised. DHT is necessary to "release" NO. All NO...

But if this were true then using tamoxifen wouldnt make sense in hypogonadal situations. Also, OP is feeling suicidal. This isnt a case of despair due to ED. It's accompanying ED as a sign of low estrogenic activity (ED likely being a symptom of too high DHT in this case, not high E2, imo...

@KovaUkko Yeah man, I know exactly how this is. I actually fucked up because I was impatient too and started HCG way too soon after crashing with aromasin. Now I know it wasn't a smart decision - it actually impeded my recovery. Ugh, I'd slap my past self a few times. Have you used/do you use...

Dont try anything just yet. Explain in detail your history. When did you take tamoxifen, how much, when did the symptoms start, when did you start TRT and so on. Mention anything that might be useful.

Zinc every day? I ask this because up to now everyone I've talked to that still experiences lingering low e2 symptoms after crashing e2 supplemented moderate to high amounts of zinc prior to crashing. Zinc has antiaromatase properties and is copper antagonizing (key mineral in estrogen...

Yes, the problem is that coconutz likely deals with either downregulated aromatase or desensitivized estrogen receptors. The prog, dhea and pregnenolone he is making him much worse in this aspect. I agree that aromasin caused this. I'm in this boat as well. Let's revaluate. Beside test, npp -...

Any update on your anhedonia/depression and libido on npp?

Interesting. It might be that in the presence of higher test levels body regulates androgen:estrogen activity with greater ease by converting preferentially to DHT since DHT can get further converted to 3b-diol which is a relatively potent estrogen (much less than estradiol, though). If it would...

Thanks for this informative reply!

Thanks for the update. Have you considered going off TRT for a HPTA reset and then going back?