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Maybe asking GPT is not a good idea. :-D

then I'll do another blood work with total T, estradiol, shbg. I'm curious to know if this high prolactin is somehow linked to the high shbg and cbg (cause or consequence). Does it make sense to check thyroid hormones?

thanks, for the info. I'm currently under no medication. Should go further on investigations with this skyscraping prolactin?

Hi all, In the last few months, I started to experience issues getting strong wood, having a late ejaculation (or even not), and way less semen. I did my blood test and voilà: (I'm not on TRT) total T: 727ng/dL shbg: 69nmol/L (lab normal range: from 18 to 54) cbg: 55 mg/L (lab normal range...

How did you compute free T? Vermeulen formula would give a result that is more 9.8ng/dl with tt=560ng/dl and 17.4ng/dl with 895ng/dl. I had quite big variations by having my blood work done after a good night of sleep or a bad night, or simply by going early to the lab or in the afternoon. Cheers

This paper is pretty interesting. The thing that puzzles me a bit is that the samples are not the same for each approach (Eq. D, cFT-x, ..). For cFT-Z, I understand since they didn't have access to the formula... For the other ones, it's a bit obscure to me.

We'll try to port this app to iPhone, actually it depends a bit of its success on Android.

Can't wait for your comments @readalot ! you made me laugh a lot with these points off the chart! thanks!

Thanks for your feedback! I'm not at home, so I've not all the sources with me, and I should ask the dev. I remember that some studies addressing multiple cohorts were applying these types of calibration. Below are two articles I found back that raise the fact that some immunoassays are biased...

Dear Excelmale members, Recently, I've been working with the help of a friend (actually he did most of the work) on an Android software that helps in the computation of free T (contains Vermeulen, Mazer, Södergård, ...) and that generates reports that link the values obtained to the current...

According to the value at the 25th percentile, we see that nearly one quarter of the athlete are with low freet (0.225nmol/L being usually used at a limit) On the other hand, I just saw that that athlete blood samples were not collected in the morning when T is peaking as in most protocols...

Several articles are showing that many athletes have an FT that is debatably low. Such in this one: http://dx.doi.org/10.1136/bjsports-2017-097792 https://pubmed.ncbi.nlm.nih.gov/29445518/ As an amateur marathoner (just about the 3hour for full-marathon), it seems that my endogenous FT...

Actually, it is maybe better to have a total T that low to have the right diagnostic. Here, in Europe, if the total T is above 400 ng/dL the MD will skip all other tests and say that it is fine.

Thanks @madman all this material! A lot to read! IMHO, the FTZ/Trut-T has some strong disadvantages: - it is proprietary - it wasn't applied yet on big cohorts (did they try to apply on EMAS or FHS datasets?) - it neglects the importance of transcotin (CBG) What is your opinion on Mazer's...

Hi FunkOdyssey, I fully agree with you, there is a lot of misunderstanding around SHBG. The sponge analogy is a very good one and shows SHBG from a totally different angle. Nevertheless, I still think that this sponge consumes a small part of the T (small since the half-life of SHBG-bound-T is...

This study used the Mazer algorithm to compute free testosterone, which might differ from Vermeulen and the gold standard equilibrium dialysis. So I order to use this table for a specific case, maybe the same formula should be used. WDYT?

thanks @Cataceous for this complete answer. when shbg becomes high for other reasons, the pituitary gland is then supposed to adapt LH in order to higher T generation to keep an acceptable free T. is that roughly the idea?

do estradiol and growth hormone test make sense as well? thanks so much

Dear all, I'm pretty amazed by this website and the quality of all the discussions in that forum. I recently did some tests because I had the feeling that something was wrong with my T level, and also because I had a shock down there while doing sport a few months ago. My result is 720 ng/dL...