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I've always been astonished at how poorly this point is conveyed by doctors and medicine in general. The vast majority of men who start TRT are still under the assumption that it is simply replacing testosterone in isolation, or 'replacing what you should have had'. The reality is anything but...

What time of day was that cortisol level pulled? Have you checked serum progesterone, TSH, cholesterol, etc?

Indian Ovidac from reliablerx works the same as the Gonasi that I used to get from my local pharmacy - 1/5th the price, too.

Certainly are. In my opinion, it'd help the vast majority of men with prostate issues if implemented appropriately - I just don't want to be seen as saying "progesterone will fix your prostate issues" when it's not so clear cut.

Depends on the application method - roughly 0.5mcg when injecting; significantly more if applying a topical oil. Just to be clear though: I'm not saying that prog fixes prostate issues, that low prog causes prostate issues, or that it'll work for anyone else - was just my anecdotal experience...

Marked physiological changes, both in-vitro and in-vivo, are observed minutes after the application of any steroid hormone. Read Selye's work - if steroid hormones didn't act immediately, you'd die upon the first exposure to any form of stressor.

Anecdotally, restoring my undetectable serum progesterone to mid-range removed my own prostate issues that arose shortly after starting TRT.

You can feel it from the first dose. Some people (particularly Rouzier) claim that any effect felt pre- the four to six week mark is entirely placebo and/or nocebo, primarily under the assumption that insufficient time has passed to alter androgen-dependant gene expression; however, a...

Have you had your thyroid function assessed - labs, but also body temperature, achilles reflex and general symptoms? I never found much benefit from TRT until I got my TSH below 1, with pre-thyroid treatment levels hovering between 2.5 - 5 (fT3/4 were always 'optimal'). Hypothyroidism can cause...

~20% IIRC.

I haven't, unfortunately. However, although test base has a short half life, the cream itself still takes a little while to absorb - I think that'd be enough to keep the HPTA suppressed. Injectable test base would be the only way to test such theory.

It's held around 30 - 35 over the last couple of years.

Very interesting - thanks for sharing your experience. Where does such dose put your serum progesterone? Pre-trt, my serum progesterone sat around 1.6 nmol/l (0.8 - 4.2), but it'd always drop to undetectable levels a month or so into HPTA suppression; HCG never did anything to help. 0.5mg...

0.5mg was injected - I should have said administration, not application.

I possess a script for prog cream, but I'll likely go with the former since it's cheaper + less additives. I've seen the same discrepancy between the effects of prog too - some dudes say it sends their libido through the roof, quells anxiety and facilitates great sleep, whereas others report the...

The genetic AGA model also fails to explain why the vast majority of men lose their hair as they age, when androgens fall and estrogen, prolactin, cortisol, etc, are all shown to rise - if genetic susceptibility + androgen receptor activation alone was the cause, men would bald in youth when...

The application would be topically on the scalp itself, mainly in attempt to produce somewhat supraphysiologcal concentrations locally whilst keeping the rise in systemic levels physiological. I wouldn't be that concerned if serum levels were elevated though given it's a largely protective...

Same experience here. Keeping my total testosterone above 34 nmol/l (1000 ng/dl) causes erectile dysfunction, absent libido, severe physical anxiety, hairloss, bloat, cognitive impairment, high blood pressure, elevated prolactin + estradiol + HCT, reduced HDL - the list could go on. My current...

Personally, I've never subscribed to the DHT 'genetic susceptibility' theory of male pattern baldness. Androgens are undoubtably involved on some level, but there's too much data associating increased prolactin, cortisol, aldosterone and estrogen (systemic, not scalp), calcification of the...