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    E2 and cancer

    I don't think that's a good way to think about it. It'd be like saying that a woman doesn't have to worry about T levels 3x the range because "think about how much T men have". Our respective bodies and brains are meant to function at different hormonal levels, I don't think you can make that...
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    Does anyone test Free E2 or Free DHT? (+ No Free DHT test on discountedlabs?)

    While almost everyone talks about and understands the importance of looking at Free T and not TT to match symptoms with lab numbers, it seems nobody talks about testing Free E2 or/and Free DHT. I'm thinking of starting to test Free E2 and Free DHT so that I can compare the free version of all 3...
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    New Atrevis Hydrogel Based Testosterone Cream from Empower: Surprising Results!

    Nelson, have you looked at your DHT (sorry if I missed it)? The scrotal application is supposed to produce much more DHT due to the presence of a high number of 5a-reductase enzymes. Any idea where your E2 stands also?
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    Is there an optimal DHEA-S range we should be aiming for?

    Check your E2. Actually you know what, I'd just start taking an AI right now if I were you, don't even wait for the lab results
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    Testosterone Gel/Cream applied to scalp?

    Compounded 20% Test cream applied to the scrotum is the only viable alternative to injections, as far as I know. my own doctor switched from injections to that cream and is liking it. If you're in the US you can get that easily through Empower and another compounding pharmacy (I forget the...
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    At What point Does Estrogen get high enough to start encouraging Gyno production?

    I know that a doctor at Defy told someone they don't like to let anyone go beyond 50pg/mL. Not sure what it's based on but you have to think they probably have one of the largest databases of bloodwork and associated symptoms out of any clinic/doctor in the world.
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    Quest Diagnostics different ranges for Free T based on methodology?

    I just did, and for my FT to come back at 240pg/mL (24ng/dL), my SHBG would have to be at 70nmol/L, which is not impossible at all since pre-TRT I was at 80nmol/L. And it's definitely possible my SHBG has rebounded from the low of 45nmol/L after I lowered my dose (higher doses lower SHBG more).
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    Quest Diagnostics different ranges for Free T based on methodology?

    How do you explain my case then? TT at 1500ng/dL and FT only at 24ng/dL (equivalent to 240pg/mL)? Again my TT dropped ~10% and my FT ~50%, how does that make sense?
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    Quest Diagnostics different ranges for Free T based on methodology?

    I agree, I actually came down from 22mg/day where my TT was 1700ng/dL, FT 370pg/mL and E2 (ultra-sensitive) 70pg/mL (range < 29). The super high E2 gave me nasty sides; hypertension (serious), bloating, depression, back acne, etc... I feel much better since dropping to 18mg/day. The weird...
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    Quest Diagnostics different ranges for Free T based on methodology?

    I'm on 18mg/day Test C shallow IM in delts. TT was 1500ng/dL, I haven't tested SHBG this time but before TRT it was very high (80) and last time around 45 (finally within range). E2 (ultra-sensitive) I'm still waiting for (only got partial results right now). Everything else is good. Lipids...
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    Quest Diagnostics different ranges for Free T based on methodology?

    I'm having some trouble understanding how different ranges relate to each other. For example, the non-Dialysis Free T mehod at Quest has a range of 46-224pg/mL for 18-69yo males (Quest Diagnostics: Test Directory). However the Dialysis Free T range shows 35-155pg/mL on my lab report. My...
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    Have You Tried Any Commercial Transdermal Testosterone Product?

    Hi Nelson, Looking at that post you mention 4 clicks per day. Do you do all 4 once in the morning or 2 in the morning and 2 in the evening? Do you find it's much more hassle than the injections? for example in terms of organizing sex around the applications, having to plan...
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    Went off TRT cold turkey today!

    I would strongly reconsider. Crashing your Test levels while going through a divorce, or even in the immediate aftermath, is about the worst possible timing. You're gonna need all the physical and mental energy you can get, trust me I'm speaking from experience. If you really can't afford it...
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    Cortisol results. Super confused.

    Basically the same. 3 vs 2.8 on 3-18 range
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    Cortisol results. Super confused.

    No, I'm doing daily Test C injections. Tried everything from 30mg/day (210mg/week) to 14mg/day (98mg/week). I feel best on 18mg/day (126mg/week). I actually feel better since I found my sweet spot of 18mg/day for Test C. Slightly more energy in the morning and more sustainable throughout the...
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    Cortisol results. Super confused.

    I think I might have the same problem you do. I've tested my Cortisol 3 times, once natural and twice on TRT. Every time (blood drawn in the morning) it came back at the very bottom of the range, even slightly lower than bottom. In the morning I'm completely unable to get up or do anything, I...
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    Depression and anxiety on TRT week 5 after great start.

    Thanks for the detailed reply. I'm going to take your advice and ride it out while I wait for the blood test results. One good thing about this doc is that he's into monitoring pretty much everything when it comes to blood work and he's on TRT himself, which to me is a good sign (put your money...
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    Depression and anxiety on TRT week 5 after great start.

    Thanks. You're right, I'm so close to getting blood work done I don't want to mess with my protocol now. It's good to know that I'm not the only one feeling this way. This is very discouraging because I've spent the entire second half of my life from 20yo feeling like absolute shit, so when I...
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    Depression and anxiety on TRT week 5 after great start.

    Thanks for replying. The doctor actually wanted to start me on twice/week IM but I insisted on daily Sub Q after reading that it would minimize side effects and provide the most stable levels. I have a bit of a perfectionism OCD so it felt like the optimal thing to do. In retrospect it might've...
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    Depression and anxiety on TRT week 5 after great start.

    I've been on TRT for almost 5 weeks (started the 5th week last monday). I didn't feel much during the first 3 weeks, but at the beginning of the 4th week I started feeling much better. Very focused and clear of mind in a way I'd never experienced before. I've had brain fog my entire life and...
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