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Currently using Enanthate.

I've been on TRT more than 20 years. The best I experienced was the first six months on Androgel. Then I started having absorption issues. I have tried about every delivery method available since then and just don't feel like I get the benefits I should. The SHGB was not even looked at back...

My SHGB is like yours. I struggle to get things right. Currently I'm doing around 180mg weekly. Curious if you inject daily?

You sound like me in many ways. I have sleep apnea too and if I don't use my machine, I feel terrible. Try the nose pillows if you haven't. Try to figure out what works for you with the machine......you'll be grateful. I had a hard time at first, but now I don't go anywhere without it. Like you...

I have really low SHGB too. What does your total and free T look like on your labs? I have been doing 12mg daily and not having much success. Appreciate any advice.

I have been following your post and am very interested in trying Jatenzo. I have struggled with every option available. I think my main problem with TRT is I have low SHBG. Just curious where your SHBG levels are at? I do a daily creme/injection now. Think this stuff might work for me? thank you.

Did you ever have any luck?

Also I donated blood after these labs, co my hematocrit level should have dropped. I have been on this regiment at least six months.

Yes, I had a sonogram done on my liver some time ago and it's caused by fatty liver (non-alcoholic). Years ago in the USAF I had the same issue, but overtime, it dropped?

This is my most resent lab. Still trying to hit the mark, but not quite there. I'm currently injecting .10 daily, due to low SHBG. I use .125 mg arimidex twice weekly, DHEA nightly and 250 IU's HCG twice weekly. I still suffer from low libido, weak ejaculation. Am I missing something? Any advice...

Curious what protocol you started? Thanks

I finally decided to go with Defy to help me out, but so far it's just adjusting things. I inject .12 daily from an insulin syringe. I do it in the shoulder. I have HCG but don't really think it helps me out? Tried a combination injection/cream....no big change either. I also was prescribed a...

You are my exact age and it seems we have the exact problem. My SHGB is around 12. I hope to follow your posts and see if you get things figured out .......like me. I even tried the pellets....bad decision. thanks for your posts......I thought I was the only one.

I have been on 200 mg weekly, but that was one injection. Of course that was also before I found I had low SHGB. I know you said you do .16 daily and it does you good. I've been doing .15 daily and I'm not so sure it's working for the better. My libido still is in the gutter. I may drop back to...

Vince....if I inject .15 daily, that's 1.05 cc's weekly and if 200mg strength.....That's a little over 200mg weekly. Is this right?

I'm sure it has to be with the high absorption with your scrotum. I was just trying to raise DHT a little to help with libido. I'm still trying to figure things out.

Sure it raised it for the first six months, but then I started having problems with absorption. This was way back when Androgel just came out. Most doctors never even tested other issues that are driven by TRT. Estrogen was never looked at, etc. I am using HCG now along with small doses of...

I'm 56yo....started Androgel when I was 38yo. Initially was the best I've ever felt, but after 6 months my body quit absorbing like in the beginning. I've tried about every delivery method since and have never came close to the first 6 months on Androgel. I just have recently discovered that I'm...

I'm 56yo and have been on some type of TRT since 38yo. You won't find many doctors out there that understand it. I'm glad for sites like this that let me know there is hope and others struggle like me. No doctor ever checked my SHGB.....I finally did it on my own. They don't understand enough...

Yes it was 24 hours after my last injection and cream.

Defy don't have me applying to scrotum....wants me to put it under arm area.

What do you think the estradiol level should be?

Thanks Vince....I was hoping you would respond. I have recently bumped up to 12mg daily. I was using 1 click of the cream to bring my DHT up....hoping to help with libido. It's not really doing anything that I can tell? I have started back with .125 arimidex three times weekly. I will try 16mg...

I've attached my latest labs to try to figure out my problems. This was after stopping arimidex. Looking for advice on this. Thank you.

I have been on HRT for at least 18 years and have never got it right. Recently joined Defy hoping to get things straightened out. I'm a low SHBG guy and currently use 1 click of the 200ml cream in the AM and .10 subQ cyp daily. I also use 500 IU's of HCG twice weekly. It just doesn't seem to...

Interested in following your progress. I have been battling HRT for many years and now I believe my low SHBG has been my main culprit. Im going to start with Defy and see if they can get me on the right track.

My sensitive E2 is 25.4 and FT 17.8.Maybe I should try and drop E2 just a little?

I’ve read many posts about how your Estrogen levels should mirror your shgb levels. What is a guy to do if his shgb levels are low? My shgb is at 12.....so what should I be seeking for E2 levels? Thanks

What would be a recommended daily dosage?

I’ve never tried any scrotal cream. Are you doing subQ injections? If so, how do you manage your lab work? I see a primary care doctor and I’m sure he will not understand subQ or why I am doing daily shots. I showed him my labs and asked about low SHBG....he said my numbers were good and all he...