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Understanding where you are getting at, I am still convinced that for the 'subset of men who do not get acceptable results with conventional TRT' that are from the US, a government approved, doctor involved, pricey insulin pump incorporating, gonadorelin available only from Hallandale...

'...the other one is from asia incl. shipping. '

I could source brand Sanofi and brand Nativa for ~$50 and ~100$. One is available locally with prescription and the other one is from asia incl. shipping. Both products last 10 months for this price at the dosage used in the study (90mcg/day=3 times 1-1 puff of 15mcg in each nostril). Now if...

I would say cost, availability and shelf-life. Also actual GnRH might need more than 3 times a day application, while buserelin also works with once a day administration at 20mcg/day according to another study if I remember correctly.

I agree with @Nelson Vergel that gonadorelin and multiple daily injections don't seem to be the way to go as a viable alternative to HCG. From the gnrh analogues buserelin acetate in a nasal spray seems most promising. Thanks to the delivery method, a 3 times a day application is not a problem...

Jatenzo presentation: https://www.fda.gov/media/110642/download

This one is interesting: American Urological Association Note that Torem has a warning for causing QT prolongation and potentially fatal torsades de pointes, so it would be smart to get an ECG and check if one takes any meds that cause QT prolongation before just jumping on it. It's also...

Wilson7, I was aware that clomid reduces IGF-1 in women, and I was aware that Tamoxifen (nolva) reduces it in men, which is one of the reasons Clomid use is preferred to Tamoxifen in men (besides Clomid also being stronger in HPTA boosting capabilities). Do you have any studies or experience...

I perfectly agree with the short term lowering of HDL being not necessarily dangerous regarding CVDs. In my experience however the LH and HDL suppressing effects of 20mg of oxandrolone/day can be nicely countered by the addition of 25mg clomid EOD. Just to clarify I have seen this work in 3...

Ostarine is worse on HDL than oxandrolone in everyone I've seen. If you are adamant on running SARMS then switching over from Ostarine to RAD-140 is kinder on HDL according to Dr Rand Mcclain (he is still no fan of SARMs). Some running oral only anabolic cycles also see an alleviation of HDL...

I'm not sure what you are getting at. I said it would help to know if your and others' real world results confirm or contradict the study results. I'm not sure how I can be categorically false about that? I also said that everyone is different and I can't hope to use the doses that worked for...

It would in the sense if it confirmed or contradicted the results I cited from the studies above. (eg.: effect is linear with dose from 0.5 to 1mg but isn't linear above, etc.) It wouldn't in the way that if the dose of 'x' mg resulted in a 'y' percent decline in your estradiol, then it should...

Do you have before-after estradiol sensitive numbers for any of the doses you used that you'd wish to share?

Arimidex or Anastrozole would be a different compound. This discussion is about Exemestane (Aromasin). Another low dose study showing 2.5mg and 5mg and 25mg having the same effect on both E2 and E1 can be found here with detailed numbers (click on the pictures) Endocrinological and clinical...

Reading this above, I'd like to discuss this a bit further: I've lately been looking into Aromasin (Exemestane) as monoteraphy and found a lot of conflicting information about dosing. Studies done on men use the female chemotheraphy dose of 25mg/day (and compared it to 50mg/day, both doses had...